Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460410 | 0.82 | PDE4B (0.44) | RIPK1 | |
| SCHEMBL2845682 | 0.81 | GRM5 (0.34) | MARS1P2RX7CNR1LMNANR3C2 | |
| SCHEMBL3250915 | 0.79 | MARS1 (0.39) | MARS1P2RX7CNR1LMNANR3C2 | |
| SCHEMBL27967501 | 0.73 | MAPK14 (0.43) | LMNA | |
| SCHEMBL1460386 | 0.67 | PDE4B (0.44) | P2RX7CNR1RIPK1 | |
| SCHEMBL3728350 | 0.66 | KDM4E (0.44) | L3MBTL1 | |
| SCHEMBL2849167 | 0.65 | GRM5 (0.35) | MARS1P2RX7CNR1LMNA | |
| SCHEMBL1722410 | 0.65 | P2RX7 (0.39) | MARS1P2RX7CNR1NR3C2L3MBTL1 | |
| SCHEMBL20550778 | 0.65 | LMNA (0.57) | MARS1P2RX7LMNANR3C2 | |
| SCHEMBL1303201 | 0.65 | MARS1 (0.43) | MARS1P2RX7CNR1LMNANR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344492-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-07-20 | — | — | EP | disclosed |