Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 7/20 | 0.43 |
| ▸ | SLC16A1 | P53985 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460387 | 0.88 | PDE4B (0.52) | HPGDNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL14944120 | 0.85 | SLC16A3 (0.42) | HPGDPOLBSLC16A3SLC16A1P2RX7 | |
| SCHEMBL1722410 | 0.84 | P2RX7 (0.39) | POLBP2RX7MEN1KMT2AMAPT | |
| SCHEMBL2845966 | 0.84 | SLC16A3 (0.42) | SLC16A3SLC16A1PDE4BMAPTALDH1A1 | |
| SCHEMBL28782961 | 0.82 | TSHR (0.48) | HPGDSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL10698208 | 0.77 | PDE4B (0.42) | HPGDNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL10388627 | 0.77 | RXRA (0.52) | HPGDNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL31522920 | 0.77 | MAPT (0.44) | RAB9ATP53KMT2AMAPK14MAPT | |
| SCHEMBL31420318 | 0.75 | GAA (0.44) | HPGDNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL12438552 | 0.75 | POLB (0.46) | HPGDSMN1; SMN2POLBSLC16A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483271-B1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SUISSE SA (CH) | 2017-08-16 | — | — | EP | disclosed |
| CN-105859712-A | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | 吉恩凯优泰克斯股份有限公司 | 2016-08-17 | — | — | CN | disclosed |
| US-9394306-B2 | Pyrazoline dione derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2016-07-19 | — | — | US | disclosed |
| US-9394306-B2 | Pyrazoline dione derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2016-07-19 | — | — | US | disclosed |
| CN-102137668-B | Pyrazolopyridine Derivatives as NADPH Oxidase Inhibitors | GENKYOTEX S.A. (CH) | 2016-05-18 | — | — | CN | disclosed |
| EP-2674160-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-10-28 | — | — | EP | disclosed |
| CN-102159573-B | Pyrazolo pyridine derivatives as nadph oxidase inhibitors | GENKYOTEX SA | 2015-05-27 | — | — | CN | disclosed |
| CN-102137863-B | Pyrazolopyridine Derivatives as NADPH Oxidase Inhibitors | GENKYOTEX SA | 2015-04-22 | — | — | CN | disclosed |
| US-9012449-B2 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-04-21 | — | — | US | disclosed |
| US-9012449-B2 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-04-21 | — | — | US | disclosed |
| CN-102137863-A | Pyrazolopyridine Derivatives as NADPH Oxidase Inhibitors | GENKYOTEX SA | 2011-07-27 | — | — | CN | disclosed |
| US-20110178081-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-07-21 | — | — | US | disclosed |
| US-20110178081-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-07-21 | — | — | US | disclosed |
| EP-2344492-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-07-20 | — | — | EP | disclosed |
| EP-2305679-A1 | Pyrazoline dione derivatives as nadph oxidase inhibitors | GenKyoTex SA (CH) | 2011-04-06 | — | — | EP | disclosed |
| EP-2305679-A1 | Pyrazoline dione derivatives as nadph oxidase inhibitors | GenKyoTex SA (CH) | 2011-04-06 | — | — | EP | disclosed |
| WO-2011036651-A1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-03-31 | — | — | WO | disclosed |
| WO-2011036651-A1 | PYRAZOLINE DIONE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-03-31 | — | — | WO | disclosed |
| WO-2010035219-A2 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2010-04-01 | — | — | WO | disclosed |
| EP-2165707-A1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYO TEX SA (CH) | 2010-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178081-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | NOX1, NOX4, CYBB | HPGD 15/4885NPC1 1716/4885RAB9A 2490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.