Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RPA1 | P27694 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14604052 | 0.86 | MAP2 (0.40) | MAP2ALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL14604429 | 0.85 | PTGS2 (0.45) | MAP2MCL1ALDH1A1SMN1; SMN2RPA1 | |
| Hydrochloric Acid SCHEMBL14604154 | 0.85 | MAP2 (0.40) | MAP2ALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL14604430 | 0.83 | MAP2 (0.35) | MAP2MCL1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14604023 | 0.80 | MAPK8 (0.53) | SMN1; SMN2MAPK8 | |
| SCHEMBL14603988 | 0.75 | MCL1 (0.49) | MAP2MCL1ALDH1A1SMN1; SMN2RPA1 | |
| SCHEMBL14604161 | 0.75 | MAPK8 (0.39) | MAP2ALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL14604245 | 0.73 | MAPK8 (0.60) | ALDH1A1MAPK8 | |
| SCHEMBL14604334 | 0.72 | GRIN1 (0.57) | MAP2MCL1LMNASMN1; SMN2MAPK8 | |
| SCHEMBL12984854 | 0.71 | LMNA (0.44) | MAP2MCL1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2731932-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-05-21 | — | — | EP | disclosed |
| WO-2013007676-A1 | AMINOMETHYL QUINOLONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-01-17 | — | — | WO | disclosed |