Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6548647 | 0.80 | POLB (0.41) | POLBL3MBTL1TSHRMEN1KMT2A | |
| SCHEMBL6442194 | 0.70 | SLC18A3 (0.44) | L3MBTL1TSHRALDH1A1HTR1A | |
| SCHEMBL21393085 | 0.68 | POLB (0.47) | POLBL3MBTL1TSHRSMN1; SMN2NOTUM | |
| SCHEMBL6444610 | 0.68 | ALDH1A1 (0.40) | TSHRALDH1A1HPGDHTR1A | |
| SCHEMBL1324873 | 0.68 | TSHR (0.44) | POLBTSHRSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6442748 | 0.68 | SLC18A3 (0.38) | POLBL3MBTL1TSHRALDH1A1GLA | |
| SCHEMBL14837450 | 0.68 | TSHR (0.44) | POLBTSHRSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL30722427 | 0.68 | CHRM2 (0.40) | TSHRALDH1A1HPGDNPSR1 | |
| SCHEMBL12199520 | 0.66 | SLC18A3 (0.43) | POLBL3MBTL1TSHRMEN1KMT2A | |
| SCHEMBL18436935 | 0.65 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2NOTUMCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820283-B1 | LACTACYSTIN ANALOGS | HARVARD COLLEGE (US) | 2007-02-14 | — | — | EP | disclosed |