Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | SCN1A | P35498 | 1/20 | 0.60 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.60 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxamine SCHEMBL30966629 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL9614282 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL146222 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL4258100 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL29763696 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL1043727 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL4258097 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL7786034 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL5172511 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL34158 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1607 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119959423-A | Method for detecting N, N-diethyl ethylenediamine ion chromatography content in methopicloram hydrochloride bulk drug | 山东齐都药业有限公司 | 2025-05-09 | — | — | CN | claimed |
| CN-119909010-A | Methoxychlor hydrochloride injection and preparation method thereof | 江西科为制药有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-119869319-A | Control method for pH value of metoclopramide hydrochloride injection | 河南润弘制药股份有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119039171-B | Industrial production of hydrochloric acid Methoxychlor-pram process | 广州市桐晖药业有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119039171-A | Industrial production of hydrochloric acid Methoxychlor-pram process | 广州市桐晖药业有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-118930442-A | Method for preparing methoxamine hydrochloride by adopting microchannel reactor | 无锡富泽药业有限公司 | 2024-11-12 | — | — | CN | claimed |
| CN-118436595-A | Methoxychlor hydrochloride injection and preparation method thereof | 遂成药业股份有限公司 | 2024-08-06 | — | — | CN | claimed |
| CN-114181097-B | Synthesis method of methoxamine hydrochloride | 广东嘉博制药有限公司 | 2024-05-14 | — | — | CN | claimed |
| CN-117776937-A | Preparation method of methoxamine hydrochloride | 常州瑞明药业有限公司 | 2024-03-29 | — | — | CN | claimed |
| CN-117752631-A | Peach gum polysaccharide nanosphere with high-efficiency double-loaded hydrophilic/hydrophobic drugs, preparation method and application | 贺州学院 | 2024-03-26 | — | — | CN | claimed |
| WO-2001092283-A2 | COBALAMIN COMPOUNDS USEFUL AS CARDIOVASCULAR AGENTS AND AS IMAGING AGENTS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2001-12-06 | — | — | WO | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| CN-1277843-A | Compound medicinal prepn. for treating acute and chronic nasosinusitis, rhinitis and tympanitis | GAO YUNDONG (CN) | 2000-12-27 | — | — | CN | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| WO-2000018447-A2 | MULTIPLEX DRUG DELIVERY SYSTEM SUITABLE FOR ORAL ADMINISTRATION | IMPAX PHARMACEUTICALS, INC. (US) | 2000-04-06 | — | — | WO | claimed |
| WO-1999051209-A1 | PRESS COATED, PULSATILE DRUG DELIVERY SYSTEM SUITABLE FOR ORAL ADMINISTRATION | IMPAX PHARMACEUTICALS, INC. (US) | 1999-10-14 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0643576-A1 | ALPHA-2-ADRENERGIC AGONISTS FOR TREATING PRESBYOPIA | TELOR OPHTHALMIC PHARMACEUTICALS, INC. (US) | 1995-03-22 | — | — | EP | claimed |
| WO-1993025199-A1 | ALPHA-2-ADRENERGIC AGONISTS FOR TREATING PRESBYOPIA | TELOR OPHTHALMIC PHARMACEUTICALS, INC. (US) | 1993-12-23 | — | — | WO | claimed |