Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | SCN1A | P35498 | 1/20 | 0.60 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.60 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxamine SCHEMBL30966629 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL146117 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL146222 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL4258100 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL29763696 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL1043727 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL4258097 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL7786034 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL5172511 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A | |
| Methoxamine SCHEMBL34158 | 0.98 | ADRA1A (1.00) | MEN1KMT2AMAPK1BLMADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0460064-A4 | THERAPEUTIC AEROSOL FORMULATIONS | — | 1992-04-01 | — | — | EP | disclosed |
| EP-0460064-A1 | THERAPEUTIC AEROSOL FORMULATIONS | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1991-12-11 | — | — | EP | disclosed |
| WO-1990009781-A1 | THERAPEUTIC AEROSOL FORMULATIONS | RORER INTERNATIONAL (HOLDINGS), INC. (US) | 1990-09-07 | — | — | WO | disclosed |