Methoxamine

Methoxamine

SCHEMBL34158

COc1ccc(OC)c(C(O)C(C)N)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1D

The experimentally established mechanism targets of Methoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A known ✓ P35348 3/20 1.00
ADRA2A P08913 2/20 1.00
CYP2D6 P10635 2/20 1.00
MEN1 O00255 1/20 0.97
MAPK1 P28482 1/20 0.97
BLM P54132 1/20 0.97
KMT2A Q03164 1/20 0.97
SCN1A P35498 1/20 0.61
SCN2A Q99250 1/20 0.61
SCN3A Q9NY46 1/20 0.61
ADRB2 P07550 1/20 0.55
ADRB1 P08588 1/20 0.55
ADRB3 P13945 1/20 0.55
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
ACHE P22303 1/20 0.51
HTT P42858 1/20 0.50
HTR2A P28223 1/20 0.50
LMNA P02545 1/20 0.49
CYP1A2 P05177 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methoxamine SCHEMBL4258100 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL5172511 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL29763696 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL5172508 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL4258097 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL1043727 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL146222 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL7786034 1.00 ADRA1A (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL146117 0.98 MEN1 (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1
Methoxamine SCHEMBL9614282 0.98 MEN1 (1.00) ADRA1AADRA2ACYP2D6MEN1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5418 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605345-B2 Transdermal drug delivery system BioPhysics Pharma, Inc. (US) 2026-04-21 US claimed
EP-4704839-A2 IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF ALPHERABIO LLC (US) 2026-03-11 EP claimed
US-20260027139-A1 TREATMENT OF SLEEP APNEA WITH A COMBINATION OF A CARBONIC ANHYDRASE INHIBITOR AND AN ALDOSTERONE ANTAGONIST VIVUS, INC. 2026-01-29 US claimed
US-12434068-B2 Accessing spinal networks to address sexual dysfunction THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-10-07 US claimed
EP-4615377-A1 DRUG-CONTAINING DEVICES, SUPRACHOROIDAL SPACE IMPLANTS, AND ADAPTERS FOR INJECTION Beijing Sightnovo Medical Technology Co., Ltd (CN) 2025-09-17 EP claimed
EP-4299106-B1 ACCESSING SPINAL NETWORK TO ENABLE RESPIRATORY FUNCTION UNIV CALIFORNIA (US) 2025-09-03 EP claimed
US-20250213647-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA 2025-07-03 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12310934-B2 Methods of treatment of spontaneous preterm birth THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-05-27 US claimed
US-20250161300-A1 COMPOSITION FOR TREATING OCULAR HYPEREMIA AND A METHOD FOR TREATING OCULAR HYPEREMIA WITH THE SAME ADS THERAPEUTICS LLC 2025-05-22 US claimed
EP-0485069-A1 Process for producing optically active amines SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1992-05-13 EP claimed
EP-0170193-B1 FEEDSTUFF ADDITIVE FOR THE GROWTH PROMOTING OF AGRICULTURAL USEFUL ANIMALS BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1991-12-27 EP claimed
US-4978332-A Reduced effect on cells distant from the site MATRIX PHARMACEUTICAL, INC. (US) 1990-12-18 US claimed
EP-0335966-A4 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS. MATRIX PHARMA INC (US) 1990-02-20 EP claimed
EP-0335966-A1 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS MATRIX PHARMACEUTICALS, INC. (US) 1989-10-11 EP claimed
US-4853216-A LIFTING HAIRS PRIOR TO DEHAIRING; FOR SHAVING CREAMS AND DEPILATORIES BRISTOL-MYERS COMPANY (US) 1989-08-01 US claimed
WO-1989002734-A1 VASOCONSTRICTIVE SUBSTANCES IN COMBINATION WITH CYTOTOXIC AGENTS MATRIX PHARMACEUTICALS, INC. (US) 1989-04-06 WO claimed
EP-0170193-A2 Feedstuff additive for the growth promoting of agricultural useful animals BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 1986-02-05 EP claimed
EP-0059057-A1 Treatment of diarrhoea BEECHAM GROUP PLC (GB) 1982-09-01 EP claimed
US-3968245-A Sympathomimetic topical and percutaneous administration with halogenated promoters ALZA CORPORATION (US) 1976-07-06 US claimed