Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 3/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | COMT | P21964 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624736 | 0.88 | FOXO1 (0.70) | FOXO1MMP2MMP9MMP8MMP13 | |
| SCHEMBL2740089 | 0.85 | RAB9A (0.68) | FOXO1MMP2MMP9MMP8MMP13 | |
| SCHEMBL2740088 | 0.82 | NPC1 (0.67) | FOXO1COMTNPC1RAB9AMEN1 | |
| SCHEMBL2624735 | 0.80 | FOXO1 (0.57) | FOXO1COMTNPC1RAB9AMEN1 | |
| SCHEMBL2740087 | 0.80 | USP2 (0.67) | FOXO1COMTNPC1RAB9AMEN1 | |
| SCHEMBL2739951 | 0.72 | NPC1 (0.61) | FOXO1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL17705602 | 0.72 | MMP2 (0.80) | MMP2MMP9MMP8MMP13COMT | |
| SCHEMBL22488975 | 0.71 | NPC1 (0.65) | FOXO1MMP2MMP9MMP8MMP13 | |
| SCHEMBL1202049 | 0.71 | NPC1 (0.60) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL22489134 | 0.71 | FOXO1 (0.58) | FOXO1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007019417-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |