Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXO1 | Q12778 | 7/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | ALPG | P10696 | 2/20 | 0.48 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22488757 | 0.92 | FOXO1 (0.70) | FOXO1CHEK1ADORA2ACDK1KDM4E | |
| SCHEMBL22489138 | 0.88 | FOXO1 (0.58) | FOXO1CHEK1NPC1POLBRAB9A | |
| SCHEMBL22489011 | 0.88 | MMP2 (0.59) | FOXO1ADORA2ACDK1KDM4EMEN1 | |
| SCHEMBL22488979 | 0.87 | NPC1 (0.61) | FOXO1KDM4EMEN1NPC1POLB | |
| SCHEMBL24513591 | 0.86 | NPC1 (0.60) | FOXO1CHEK1CDK1KDM4EMEN1 | |
| SCHEMBL22488747 | 0.86 | ADORA2A (0.60) | FOXO1CHEK1ADORA2ACDK1KDM4E | |
| SCHEMBL22488976 | 0.86 | NPC1 (0.60) | FOXO1CDK1KDM4EMEN1NPC1 | |
| SCHEMBL22488975 | 0.85 | NPC1 (0.65) | FOXO1CDK1KDM4EMEN1NPC1 | |
| SCHEMBL22488981 | 0.84 | NPC1 (0.64) | FOXO1CDK1KDM4EMEN1NPC1 | |
| SCHEMBL22488995 | 0.84 | FOXO1 (0.68) | FOXO1KDM4EMEN1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185797-A1 | SELECTIVE FOXO INHIBITORS FOR TREATMENT OF DIABETES AND OTHER DISORDERS RELATED TO IMPAIRED PANCREATIC FUNCTION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2022-06-16 | — | — | US | disclosed |
| WO-2020198351-A1 | SELECTIVE FOXO INHIBITORS FOR TREATMENT OF DIABETES AND OTHER DISORDERS RELATED TO IMPAIRED PANCREATIC FUNCTION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185797-A1 | SELECTIVE FOXO INHIBITORS FOR TREATMENT OF DIABETES AND OTHER DISORDERS RELATED TO IMPAIRED PANCREATIC FUNCTION | FOXO1, FOXO3, FOXK1 | FOXO1 1/4885CHEK1 1693/4885ADORA2A 4574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.