Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12010809 | 0.77 | ALDH1A1 (0.41) | ALDH1A1SIGMAR1MAOAMAOBSLC6A4 | |
| SCHEMBL12853764 | 0.76 | SLC6A4 (0.45) | ALDH1A1TSHRATMNPSR1SLC6A4 | |
| SCHEMBL10066156 | 0.76 | MAOA (0.52) | MAOAMAOBSLC6A4HRH3DRD2 | |
| SCHEMBL19339186 | 0.75 | ALDH1A1 (0.42) | ALDH1A1TSHRATMNPSR1SIGMAR1 | |
| SCHEMBL22541985 | 0.74 | MAOA (0.51) | MAOAMAOBSLC6A4HRH3DRD2 | |
| SCHEMBL12683145 | 0.74 | MAOA (0.50) | MAOAMAOBSLC6A4DRD2DRD3 | |
| SCHEMBL24253498 | 0.73 | DRD2 (0.51) | MAOAMAOBSLC6A4HRH3DRD2 | |
| SCHEMBL22993218 | 0.72 | MAOA (0.47) | MAOAMAOBSLC6A4HRH3DRD2 | |
| SCHEMBL22993217 | 0.72 | MAOA (0.47) | MAOAMAOBSLC6A4HRH3DRD2 | |
| SCHEMBL10039921 | 0.71 | MAOA (0.55) | MAOAMAOBSLC6A4HRH3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757584-A1 | Heterocyclic substituted amides, their production and their use | Abbott GmbH & Co. KG (DE) | 2007-02-28 | — | — | EP | disclosed |