Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.37 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1341149 | 0.92 | HSP90AB1 (0.45) | HSP90AA1HSP90AB1ATP4AATP4BKDM4E | |
| SCHEMBL1148670 | 0.72 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ATP4AATP4B | |
| SCHEMBL16488462 | 0.65 | ATP4A (0.40) | HSP90AA1HSP90AB1ATP4AATP4B | |
| SCHEMBL14618214 | 0.64 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1 | |
| SCHEMBL1343952 | 0.64 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1 | |
| SCHEMBL1343450 | 0.63 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1ATP4AATP4B | |
| SCHEMBL1148685 | 0.63 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1 | |
| SCHEMBL14618451 | 0.63 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL1343583 | 0.62 | ALDH1A1 (0.38) | HSP90AA1HSP90AB1KDM4EALDH1A1LMNA | |
| SCHEMBL1747096 | 0.62 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNACYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021877-A1 | IMIDAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-02-22 | — | — | WO | disclosed |