Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDCBP | O00560 | 3/20 | 0.50 |
| ▸ | SDC2 | P34741 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14626373 | 1.00 | SDCBP (0.50) | SDCBPSDC2MEN1KMT2AALDH1A1 | |
| SCHEMBL5711363 | 0.86 | ALDH1A1 (0.56) | SDCBPSDC2ALDH1A1MAPTFNTA | |
| SCHEMBL6446379 | 0.86 | ALDH1A1 (0.56) | SDCBPSDC2ALDH1A1MAPTFNTA | |
| SCHEMBL18086761 | 0.84 | SMN1; SMN2 (0.58) | MEN1KMT2AALDH1A1KDM4ELMNA | |
| SCHEMBL5368224 | 0.80 | IAPP (0.50) | SDCBPSDC2MEN1KMT2AALDH1A1 | |
| SCHEMBL23966258 | 0.77 | POLB (0.53) | MEN1KMT2ALMNAMAPTPOLB | |
| SCHEMBL5370771 | 0.77 | HSD17B10 (0.50) | SDCBPSDC2MEN1KMT2AALDH1A1 | |
| SCHEMBL26616556 | 0.77 | SMN1; SMN2 (0.67) | KMT2AALDH1A1LMNAFNTAFNTB | |
| SCHEMBL9503736 | 0.77 | SMN1; SMN2 (0.67) | KMT2AALDH1A1LMNAFNTAFNTB | |
| SCHEMBL27964613 | 0.76 | KMT2A (0.68) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169798-B2 | Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-01-30 | — | — | US | disclosed |