SCHEMBL14629293

SCHEMBL14629293

N#Cc1ncc2cc3ccccc3cc2n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 2/20 0.41
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NQO2 P16083 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2A6 P11509 1/20 0.38
PDPK1 O15530 1/20 0.38
CSNK1D P48730 1/20 0.38
CSNK1E P49674 1/20 0.38
CLK1 P49759 1/20 0.38
DYRK1A Q13627 1/20 0.38
CTSS P25774 4/20 0.37
CTSK P43235 3/20 0.37
NAAA Q02083 1/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 2/20 0.36
GAA P10253 1/20 0.36
GLA P06280 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29947454 0.82 ALDH1A1 (0.43) CHEK1ATML3MBTL1CYP1A2CTSS
SCHEMBL1996212 0.82 ALDH1A1 (0.43) CHEK1ATML3MBTL1CYP1A2CTSS
SCHEMBL14629285 0.77 ALDH1A1 (0.45) CHEK1CYP1A2CTSSCTSKALDH1A1
SCHEMBL30718705 0.73 PKM (0.44) NQO2CYP1A2CYP2A6CTSSALDH1A1
SCHEMBL12033738 0.71 CYP1A2 (0.52) NQO2CYP1A2CYP2A6PDPK1CSNK1D
SCHEMBL4984360 0.70 HPGDS (0.57) CHEK1NQO2CYP1A2ALDH1A1CA1
SCHEMBL14629283 0.69 NQO1 (0.56) CHEK1NQO2CTSKALDH1A1KDM4E
SCHEMBL31587903 0.68 CHEK1 (0.62) CHEK1ATML3MBTL1CYP1A2CYP2A6
SCHEMBL507331 0.68 CHEK1 (0.62) CHEK1ATML3MBTL1CYP1A2CYP2A6
SCHEMBL5436850 0.68 KDM4D (0.41) CTSSCTSKALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1739081-A1 HYDRAZINO-SUBSTITUTED HETEROCYCLIC NITRILE COMPOUNDS AND USE THEREOF ONO PHARMACEUTICAL CO., LTD. (JP) 2007-01-03 EP disclosed