SCHEMBL146303

SCHEMBL146303

N#Cc1nc2ccc(N)cc2s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.56
MAPT P10636 11/20 0.53
GAA P10253 5/20 0.53
RAB9A P51151 5/20 0.53
NPC1 O15118 4/20 0.53
KDM4E B2RXH2 3/20 0.53
GLA P06280 3/20 0.53
KEAP1 Q14145 1/20 0.51
APP P05067 2/20 0.51
ALDH1A1 P00352 3/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
PKM P14618 2/20 0.50
HPGD P15428 2/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA4 P22748 1/20 0.50
TP53 P04637 2/20 0.49
POLB P06746 1/20 0.49
PTBP1 P26599 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25137597 0.86 MAPT (0.53) SMN1; SMN2MAPTGAARAB9ANPC1
SCHEMBL12312850 0.83 MAPT (0.54) SMN1; SMN2MAPTGAARAB9ANPC1
SCHEMBL29409281 0.79 HTT (0.56) MAPTGAAAPPCA1CA2
SCHEMBL20681327 0.79 DYRK1A (0.42) MAPTKDM4EAPPALDH1A1MEN1
SCHEMBL12312853 0.79 NPC1 (0.56) SMN1; SMN2MAPTGAARAB9ANPC1
SCHEMBL19190176 0.79 APP (0.44) SMN1; SMN2MAPTGAARAB9ANPC1
SCHEMBL140656 0.79 HTT (0.56) MAPTGAAAPPCA1CA2
SCHEMBL730573 0.79 RAB9A (0.49) SMN1; SMN2MAPTRAB9ANPC1APP
SCHEMBL12872411 0.79 RAB9A (0.56) SMN1; SMN2MAPTGAARAB9ANPC1
SCHEMBL7548821 0.79 GFER (0.56) SMN1; SMN2MAPTGAARAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 318 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122060052-A Method for chemically modifying nano antibody by site specificity and application thereof 哈尔滨工业大学 2026-05-19 CN claimed
CN-117462675-B Preparation method and application of engineering bacterium loaded functionalized melanin nano-system compound 郑州大学 2026-05-12 CN claimed
CN-118490852-B Intracellular-constructed legumain-responded PET/MR bimodal molecular probe and application thereof 安徽医科大学第一附属医院 2025-05-16 CN claimed
CN-118490852-A Intracellular-constructed legumain-responded PET/MR bimodal molecular probe and application thereof 安徽医科大学第一附属医院 2024-08-16 CN claimed
CN-117462675-A Preparation method and application of engineering bacterium loaded functionalized melanin nano-system compound 郑州大学 2024-01-30 CN claimed
CN-116297413-A Application of amino luciferin derivative bioluminescence probe in malaria diagnosis 山东大学第二医院 2023-06-23 CN claimed
US-20230105741-A1 PHOTOREACTIVE AND CLEAVABLE PROBES FOR TAGGING BIOMOLECULES Syncell (Taiwan) Inc. (TW) 2023-04-06 US claimed
CN-109824622-B Prodrug forming nano structure in cell to kill cancer cell and its prepn 中国科学技术大学 2022-12-30 CN claimed
CN-115141253-A T for CTSB response constructed in cells 2 Small molecule magnetic resonance contrast agent and preparation method thereof 中国科学技术大学 2022-10-04 CN claimed
CN-111420053-B Multifunctional magnetic nanoparticle compound capable of intracellular aggregation and preparation method thereof 珠海市人民医院 2022-09-09 CN claimed
US-20180079906-A1 AZACYANINE DYES AND USE THEREOF Ecole polytechnique fédérale de Lausanne (EPFL) (CH) 2018-03-22 US claimed
CN-106967152-A Compound that a kind of fluorine 18 is marked and preparation method and application 江苏省原子医学研究所 2017-07-21 CN claimed
WO-2014057139-A2 PRECURSOR MOLECULE FOR THE SYNTHESIS OF D-LUCIFERIN ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2014-04-17 WO claimed
EP-2719703-A1 Precursor molecule for the synthesis of D-luciferin Ecole Polytechnique Fédérale de Lausanne (EPFL) (CH) 2014-04-16 EP claimed
US-8586759-B2 Methods and systems for synthesis of a D-aminoluciferin precursor and related compounds LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) 2013-11-19 US claimed
US-20110224442-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (LLNS) 2011-09-15 US claimed
US-20110213124-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS LAWRENCE LIVERMORE NATIONAL SECURITY, LLC 2011-09-01 US claimed
EP-0300001-B1 AMINOLUCIFERINES, PROCESS FOR PRODUCING SAME AND USE THEREOF Geiger, Reinhard, Dr. (DE) 1992-10-28 EP claimed
EP-0300001-A1 AMINOLUCIFERINES, PROCESS FOR PRODUCING SAME AND USE THEREOF. GEIGER REINHARD DR (DE) 1989-01-25 EP claimed
WO-1988005434-A1 AMINOLUCIFERINES, PROCESS FOR PRODUCING SAME AND USE THEREOF GEIGER REINHARD (DE) 1988-07-28 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224442-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS HCCS, HLCS, GLUL SMN1; SMN2 4724/4885MAPT 4518/4885GAA 1123/4885
US-20110213124-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS HCCS, HLCS, GLUL SMN1; SMN2 4724/4885MAPT 4518/4885GAA 1123/4885
US-20180079906-A1 AZACYANINE DYES AND USE THEREOF INMT, AZI2, MYADM SMN1; SMN2 2777/4885MAPT 3491/4885GAA 2988/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.