⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1462116 | 0.74 | — | — | |
| SCHEMBL2423602 | 0.73 | — | — | |
| Phosphine SCHEMBL27645652 | 0.71 | — | — | |
| SCHEMBL3480583 | 0.71 | HPGD (0.41) | — | |
| SCHEMBL295632 | 0.70 | EHMT2 (0.48) | — | |
| SCHEMBL15610445 | 0.68 | LMNA (0.36) | — | |
| SCHEMBL3145825 | 0.68 | GRM5 (0.33) | — | |
| SCHEMBL998823 | 0.68 | — | — | |
| SCHEMBL924231 | 0.68 | MTOR (0.36) | — | |
| SCHEMBL6642579 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848506-B | Biphenyl urea compound and pharmaceutical composition, preparation method and application thereof | 中国药科大学 | 2023-01-31 | — | — | CN | claimed |
| CN-113788827-A | Phthalazinone compounds, preparation method and medical application thereof | 中国药科大学 | 2021-12-14 | — | — | CN | claimed |
| CN-113717159-A | Indolone compounds and pharmaceutical composition, preparation method and application thereof | 中国药科大学 | 2021-11-30 | — | — | CN | claimed |
| CN-111848506-A | Biphenyl urea compound and pharmaceutical composition, preparation method and application thereof | 中国药科大学 | 2020-10-30 | — | — | CN | claimed |
| EP-1027056-B1 | ALPHA-KETOAMIDE MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2009-02-25 | — | — | EP | claimed |
| US-20230201161-A1 | Combination comprising HDAC inhibitor, LAG-3 inhibitor and a PD-1 inhibitor or PD-L1 inhibitor for cancer treatment | 4SC AG (DE) | 2023-06-29 | — | — | US | disclosed |
| CN-111848506-B | Biphenyl urea compound and pharmaceutical composition, preparation method and application thereof | 中国药科大学 | 2023-01-31 | — | — | CN | disclosed |
| CN-115443262-A | Method for producing alpha-fluoroacrylate | 大金工业株式会社 | 2022-12-06 | — | — | CN | disclosed |
| CN-115427387-A | Method for producing alpha-fluoroacrylate | 大金工业株式会社 | 2022-12-02 | — | — | CN | disclosed |
| CN-108834409-B | Process for producing fluorine-containing compound | 大金工业株式会社 | 2022-11-01 | — | — | CN | disclosed |
| CN-115181005-A | Process for producing fluorine-containing compound | 大金工业株式会社 | 2022-10-14 | — | — | CN | disclosed |
| CN-110121500-B | 4H-pyrrolopyridine compound or salt thereof, agricultural or horticultural insecticide containing same, and method for using same | 日本农药株式会社 | 2022-05-03 | — | — | CN | disclosed |
| WO-2000059503-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000059502-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000059498-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |
| EP-1027056-A1 | ALPHA-KETOAMIDE MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 2000-08-16 | — | — | EP | disclosed |
| US-6096778-A | A PEPTIDE DERIVATIVE USEFUL FOR THE TREATMENT OF MUSCLE WASTING DISORDERS | CEPHALON, INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-1021199-A1 | PEPTIDE-CONTAINING $g(a)-KETOAMIDE CYSTEINE AND SERINE PROTEASE INHIBITORS | CEPHALON, INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017778-A1 | α-KETOAMIDE MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC. (US) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999017790-A1 | PEPTIDE-CONTAINING α-KETOAMIDE CYSTEINE AND SERINE PROTEASE INHIBITORS | CEPHALON INC. (US) | 1999-04-15 | — | — | WO | disclosed |