Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27837187 | 0.88 | ALOX5 (0.54) | PTGDR2PTGS1PTGS2SMN1; SMN2KDM4E | |
| SCHEMBL14631970 | 0.88 | ALOX5 (0.46) | PTGS1PTGS2SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL14631965 | 0.86 | ALOX5 (0.57) | PTGS1PTGS2SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL14632061 | 0.82 | KDM4E (0.43) | KDM4ENPC1ALDH1A1ALOX5MAPT | |
| SCHEMBL14632042 | 0.81 | ALPL (0.40) | SMN1; SMN2ALDH1A1L3MBTL1ALOX5MAPT | |
| SCHEMBL269233 | 0.77 | SMN1; SMN2 (0.51) | PTGDR2PTGS1PTGS2SMN1; SMN2KDM4E | |
| SCHEMBL27824201 | 0.76 | ALOX5 (0.56) | SMN1; SMN2KDM4ERAB9ANPC1ALOX5 | |
| SCHEMBL28790280 | 0.76 | ALOX5 (0.73) | PTGS1PTGS2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14632067 | 0.75 | TRPM8 (0.44) | SMN1; SMN2KDM4EALOX5TRPM8HCRTR1 | |
| SCHEMBL14631942 | 0.75 | ALOX5 (0.44) | SMN1; SMN2KDM4ERAB9APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188282-B1 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-01-23 | — | — | EP | claimed |