Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28488019 | 0.93 | HDAC6 (0.34) | — | |
| SCHEMBL17193578 | 0.88 | CA1 (0.32) | LMNA | |
| SCHEMBL1463203 | 0.82 | — | — | |
| SCHEMBL7207172 | 0.80 | LMNA (0.42) | ALDH1A1LMNAHSD17B10GAA | |
| SCHEMBL611230 | 0.76 | ALDH1A1 (0.35) | ALDH1A1SOAT1 | |
| SCHEMBL11331559 | 0.72 | ALDH1A1 (0.36) | ALDH1A1GAASOAT1 | |
| SCHEMBL475144 | 0.72 | TSHR (0.43) | ALDH1A1GAASOAT1 | |
| SCHEMBL10710350 | 0.71 | TSHR (0.32) | ALDH1A1GAA | |
| SCHEMBL2347789 | 0.71 | TSHR (0.32) | ALDH1A1GAA | |
| SCHEMBL17791794 | 0.70 | ALDH1A1 (0.36) | ALDH1A1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102026966-B | Novel amino acid derivatives, preparation method and therapeutic use thereof | PHARMALEADS | 2014-02-12 | — | — | CN | disclosed |
| US-8466309-B2 | Amino acid derivatives, method for preparing same, and therapeutic use thereof | KOS THERAPEUTICS, INC. | 2013-06-18 | — | — | US | disclosed |
| US-8247608-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | PHARMALEADS (FR) | 2012-08-21 | — | — | US | disclosed |
| US-8247609-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | Pharamleads (FR) | 2012-08-21 | — | — | US | disclosed |
| EP-1940818-B1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2011-08-24 | — | — | EP | disclosed |
| CN-102026966-A | Novel amino acid derivatives, preparation method and therapeutic use thereof | PHARMALEADS | 2011-04-20 | — | — | CN | disclosed |
| US-20110071218-A1 | NOVEL AMINO ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF | PHARMALEADS (FR) | 2011-03-24 | — | — | US | disclosed |
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | PHARMALEADS (FR) | 2009-05-21 | — | — | US | disclosed |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2009-01-08 | — | — | US | disclosed |
| EP-1940818-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | Pharmaleads (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007048787-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2007-05-03 | — | — | WO | disclosed |
| US-4826832-A | BACTERICIDES | CIBA-GEIGY CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| US-4794109-A | 6-hydroxy-lower alkylpenem compounds, pharmaceutical preparations that contain these compounds, and the use of the latter | CIBA-GEIGY CORPORATION (US) | 1988-12-27 | — | — | US | disclosed |
| US-4656165-A | Aminomethyl penem compounds | CIBA-GEIGY CORPORATION (US) | 1987-04-07 | — | — | US | disclosed |
| US-4616007-A | PENICILLINS | CIBA-GEIGY CORPORATION (US) | 1986-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | HRH4, OPRL1, CNR2 | ALDH1A1 617/4885LMNA 4779/4885HSD17B10 684/4885 |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | HRH4, CNR2, OPRM1 | ALDH1A1 591/4885LMNA 4699/4885HSD17B10 689/4885 |
| US-20110071218-A1 | NOVEL AMINO ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF | CNR1, OPRD1, OPRM1 | ALDH1A1 2630/4885LMNA 4557/4885HSD17B10 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.