Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2455033 | 0.80 | GRM5 (0.39) | KMT2ACHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL137980 | 0.76 | GPR119 (0.43) | RIPK1KMT2A | |
| SCHEMBL7254321 | 0.72 | L3MBTL1 (0.47) | KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL29777103 | 0.70 | SRC (0.37) | KMT2AALDH1A1 | |
| SCHEMBL29080040 | 0.70 | GPR119 (0.45) | KMT2A | |
| SCHEMBL10210462 | 0.68 | PIK3CD (0.37) | LMNAKMT2A | |
| SCHEMBL23208609 | 0.68 | ALDH1A1 (0.36) | KMT2AALDH1A1TSHRL3MBTL1 | |
| SCHEMBL813145 | 0.67 | MCL1 (0.40) | LMNAALDH1A1ALOX15TSHRL3MBTL1 | |
| SCHEMBL2729302 | 0.67 | MAPT (0.42) | LMNAKMT2AALDH1A1ALOX15TSHR | |
| SCHEMBL813136 | 0.66 | MCL1 (0.46) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734205-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | Tolero Pharmaceuticals, Inc. (US) | 2014-05-28 | — | — | EP | disclosed |
| WO-2013013188-A1 | HETEROCYCLIC PROTEIN KINASE INHIBITORS | TOLERO PHARMACEUTICALS, INC. (US) | 2013-01-24 | — | — | WO | disclosed |