Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379165 | 0.89 | HTT (0.52) | KMT2AALDH1A1SMN1; SMN2MEN1KDM4E | |
| SCHEMBL12298503 | 0.73 | EPHX2 (0.44) | EPHX2HTTPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4967823 | 0.71 | RAB9A (0.60) | KMT2AALDH1A1SMN1; SMN2MEN1MAPT | |
| SCHEMBL12297424 | 0.71 | NTSR1 (0.39) | EPHX2KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL20353537 | 0.70 | ALDH1A1 (0.65) | KMT2AALDH1A1SMN1; SMN2MEN1KDM4E | |
| SCHEMBL8187973 | 0.68 | IMPDH2 (0.45) | KMT2AALDH1A1SMN1; SMN2MEN1KDM4E | |
| SCHEMBL13459817 | 0.66 | TRPV1 (0.53) | KDM4EIMPDH2TRPV1ROCK2 | |
| SCHEMBL6968376 | 0.66 | KDM4E (0.47) | KMT2AALDH1A1SMN1; SMN2MEN1KDM4E | |
| SCHEMBL17932555 | 0.66 | TNF (0.49) | KDM4ENPC1RAB9APIK3CDPIK3CB | |
| SCHEMBL2379761 | 0.65 | SIRT2 (0.49) | KMT2AALDH1A1SMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007005668-A2 | BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-01-11 | — | — | WO | disclosed |