SCHEMBL14640545

SCHEMBL14640545

C=C(C)c1cc(C(=O)Nc2ccc(C(F)(F)F)cc2)n(C)n1

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.56
KMT2A Q03164 4/20 0.56
RXFP1 Q9HBX9 1/20 0.56
MAPT P10636 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
ALDH1A1 P00352 2/20 0.48
CYP3A4 P08684 1/20 0.48
HSD17B10 Q99714 1/20 0.48
POLB P06746 1/20 0.48
NR3C1 P04150 4/20 0.47
TSHR P16473 1/20 0.46
ROCK1 Q13464 1/20 0.46
TRPV1 Q8NER1 1/20 0.46
LMNA P02545 1/20 0.46
HPGD P15428 1/20 0.46
HIF1A Q16665 1/20 0.46
FLT1 P17948 1/20 0.45
KDR P35968 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6059993 0.80 POLB (0.58) MEN1KMT2AMAPTNPSR1ALDH1A1
SCHEMBL28124049 0.76 HDAC3 (0.53) MEN1KMT2AMAPTNPSR1ALDH1A1
SCHEMBL14937993 0.74 NPC1 (0.68) MEN1KMT2AMAPTNPSR1ALDH1A1
SCHEMBL1828447 0.71 F10 (0.52) MEN1KMT2ARXFP1MAPTNPSR1
SCHEMBL13078556 0.70 MEN1 (0.40) MEN1KMT2ARXFP1MAPTALDH1A1
SCHEMBL1900620 0.70 MAPK14 (0.59) MEN1KMT2ARXFP1MAPTNPSR1
SCHEMBL14893308 0.69 CYP3A4 (0.69) MEN1KMT2ARXFP1MAPTALDH1A1
SCHEMBL19710265 0.68 ALDH1A1 (0.65) MAPTNPSR1ALDH1A1CYP3A4HSD17B10
SCHEMBL13168267 0.68 MEN1 (0.41) MEN1KMT2ARXFP1MAPTALDH1A1
SCHEMBL7779037 0.68 EPHX2 (0.61) MEN1KMT2ARXFP1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070021509-A1 Phosphate transport inhibitors JOZEFIAK THOMAS H 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021509-A1 Phosphate transport inhibitors SLC34A2, SLC34A1, SLC20A1 MEN1 2248/4885KMT2A 4634/4885RXFP1 949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.