Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | GLB1 | P16278 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | CTRC | Q99895 | 1/20 | 0.58 |
| ▸ | GNG2 | P59768 | 1/20 | 0.44 |
| ▸ | GNB1 | P62873 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1444969 | 0.88 | SMAD3 (0.77) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL1463748 | 0.88 | SMAD3 (0.65) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| Bromide SCHEMBL22494505 | 0.87 | SMAD3 (0.75) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL1464049 | 0.87 | SMAD3 (0.64) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL23389601 | 0.86 | SMAD3 (0.66) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL23860296 | 0.86 | SMAD3 (0.66) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL3420556 | 0.82 | SMAD3 (0.58) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL23389672 | 0.80 | SMAD3 (0.69) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL1444919 | 0.80 | THRB (0.85) | SMAD3ALDH1A1THRBRECQLTDP1 | |
| SCHEMBL9305980 | 0.80 | THRB (0.85) | SMAD3ALDH1A1THRBRECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422260-B2 | Process for the synthesis of 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodo-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one(Rose Bengal) and related xanthenes | PROVECTUS PHARMATECH, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9273022-B2 | Process for the synthesis of 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′, 4′, 5′7′-tetraiodo-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (Rose Bengal) and related xanthenes | PROVECTUS PHARMACEUTICALS, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-2464225-B1 | PROCESS FOR THE SYNTHESIS OF 4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-2',4',5'7'-TETRAIODO-3H-SPIRO[ISOBENZOFURAN-1,9'-XANTHEN]-3-ONE (ROSE BENGAL) AND RELATED XANTHENES | PROVECTUS PHARMATECH INC (US) | 2015-09-16 | — | — | EP | disclosed |
| US-20140343296-A1 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes | TIMOTHY WILLIAMS REVOCABLE TRUST | 2014-11-20 | — | — | US | disclosed |
| US-20130274322-A1 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one(Rose Bengal) and Related Xanthenes | PROVECTUS PHARMACEUTICALS, INC. | 2013-10-17 | — | — | US | disclosed |
| US-8530675-B2 | Process for the synthesis of 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodo-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (rose bengal) and related xanthenes | PROVECTUS PHARMACEUTICALS, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110071217-A1 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes | PROVECTUS PHARMACEUTICALS, INC. | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071217-A1 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes | TPO, MPO, NISCH | SMAD3 4320/4885ALDH1A1 483/4885THRB 184/4885 |
| US-20140343296-A1 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one (Rose Bengal) and Related Xanthenes | TPO, MPO, NISCH | SMAD3 4320/4885ALDH1A1 483/4885THRB 184/4885 |
| US-20130274322-A1 | Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one(Rose Bengal) and Related Xanthenes | TPO, MPO, NISCH | SMAD3 4320/4885ALDH1A1 483/4885THRB 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.