Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14641589 | 0.90 | MET (0.49) | METNQO2GSK3BPOLBSMN1; SMN2 | |
| SCHEMBL12241160 | 0.80 | MET (0.50) | METNQO2POLB | |
| SCHEMBL22309754 | 0.76 | MET (0.58) | METNQO2SMN1; SMN2CXCR1 | |
| SCHEMBL1296276 | 0.75 | MET (0.57) | METNQO2CHRM3CXCR1 | |
| SCHEMBL31495087 | 0.73 | MET (0.57) | METNQO2CXCR1 | |
| SCHEMBL12547598 | 0.73 | MET (0.57) | METNQO2CXCR1 | |
| SCHEMBL13981879 | 0.73 | ACHE (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL16697161 | 0.73 | MET (0.44) | METNQO2ADORA2BADORA1 | |
| SCHEMBL23344107 | 0.73 | MET (0.54) | METNQO2POLBCXCR1 | |
| SCHEMBL14641595 | 0.72 | POLB (0.39) | POLBSMN1; SMN2MAPK1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |