Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | USP1 | O94782 | 4/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14641588 | 0.85 | USP1 (0.43) | METUSP1 | |
| SCHEMBL14641587 | 0.85 | USP1 (0.41) | METUSP1 | |
| SCHEMBL14641623 | 0.81 | MET (0.42) | METUSP1BMPR1AACVRL1ACVR1 | |
| SCHEMBL12241122 | 0.80 | MET (0.52) | METADORA2AADORA1BMPR1AACVRL1 | |
| SCHEMBL12547692 | 0.78 | MET (0.53) | METADORA2AADORA1BMPR1AACVRL1 | |
| SCHEMBL14641564 | 0.78 | USP1 (0.43) | METUSP1 | |
| SCHEMBL14641562 | 0.77 | MET (0.42) | METADORA2AUSP1 | |
| SCHEMBL1579381 | 0.75 | MET (0.56) | MET | |
| SCHEMBL1579491 | 0.75 | MET (0.56) | MET | |
| SCHEMBL1300735 | 0.75 | MET (0.56) | METACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |