Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 17/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14641622 | 0.85 | MET (0.52) | USP1MET | |
| SCHEMBL14641587 | 0.81 | USP1 (0.41) | USP1MET | |
| SCHEMBL14641623 | 0.78 | MET (0.42) | USP1MET | |
| SCHEMBL14641564 | 0.76 | USP1 (0.43) | USP1MET | |
| SCHEMBL14641562 | 0.75 | MET (0.42) | USP1MET | |
| SCHEMBL12241240 | 0.73 | ALDH1A1 (0.42) | MET | |
| SCHEMBL12241122 | 0.66 | MET (0.52) | MET | |
| SCHEMBL3083882 | 0.65 | MET (0.58) | MET | |
| SCHEMBL12547692 | 0.63 | MET (0.53) | MET | |
| SCHEMBL13981975 | 0.63 | MET (0.51) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |