SCHEMBL14645960

SCHEMBL14645960

COc1c(C(C)(C)C)cc2c(c1-c1ccccc1)C=C(C)C2[Si](C)(C)Cl

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 4/20 0.34
PDE4A P27815 3/20 0.34
PDE4C Q08493 3/20 0.34
PDE4D Q08499 3/20 0.34
TNFRSF1A P19438 1/20 0.31
ALDH1A1 P00352 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3736095 0.91 PDE4B (0.35) PDE4BPDE4APDE4CPDE4DTNFRSF1A
SCHEMBL15700813 0.91 PDE4B (0.35) PDE4BPDE4APDE4CPDE4DTNFRSF1A
SCHEMBL14645946 0.90 TDO2 (0.32)
SCHEMBL20165756 0.87 PTGS2 (0.30)
SCHEMBL29992354 0.87 PTGS2 (0.30)
SCHEMBL14645995 0.86 PTGS2 (0.30)
SCHEMBL15893457 0.86
SCHEMBL15672462 0.86 PDE4B (0.34) PDE4BPDE4APDE4CPDE4DALDH1A1
SCHEMBL27189773 0.86 PDE4A (0.32) PDE4BPDE4APDE4CPDE4D
SCHEMBL14645950 0.85 PTGS1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2722345-B1 CATALYST FOR THE POLYMERISATION OF OLEFINS BOREALIS AG (AT) 2018-12-05 EP disclosed
EP-2746289-B1 Catalysts BOREALIS AG (AT) 2017-09-27 EP disclosed
EP-2729479-B1 CATALYSTS BOREALIS AG (AT) 2017-09-06 EP disclosed
US-9630980-B2 Asymmetrical ligands BOREALIS AG (AT) 2017-04-25 US disclosed
US-9630980-B2 Asymmetrical ligands BOREALIS AG (AT) 2017-04-25 US disclosed
EP-2722344-B1 POLYMERISATION PROCESS BOREALIS AG (AT) 2017-03-22 EP disclosed
US-9567351-B2 Heterophasic copolymers BOREALIS AG (AT) 2017-02-14 US disclosed
US-9567351-B2 Heterophasic copolymers BOREALIS AG (AT) 2017-02-14 US disclosed
US-9475890-B2 Catalyst BOREALIS AG (AT) 2016-10-25 US disclosed
US-9475890-B2 Catalyst BOREALIS AG (AT) 2016-10-25 US disclosed
WO-2014060534-A1 CATALYST BOREALIS AG (AT) 2014-04-24 WO disclosed
WO-2014060534-A1 CATALYST BOREALIS AG (AT) 2014-04-24 WO disclosed
WO-2014060540-A1 POLYMERISATION PROCESS AND CATALYST BOREALIS AG (AT) 2014-04-24 WO disclosed
WO-2014060540-A1 POLYMERISATION PROCESS AND CATALYST BOREALIS AG (AT) 2014-04-24 WO disclosed
EP-2722346-A1 Polymerisation process and catalyst Borealis AG (AT) 2014-04-23 EP disclosed
EP-2722344-A1 Polymerisation process Borealis AG (AT) 2014-04-23 EP disclosed
EP-2722345-A1 Catalyst Borealis AG (AT) 2014-04-23 EP disclosed
EP-2722346-A1 Polymerisation process and catalyst Borealis AG (AT) 2014-04-23 EP disclosed
WO-2013007664-A1 HETEROPHASIC COPOLYMERS BOREALIS AG (AT) 2013-01-17 WO disclosed
WO-2013007650-A1 CATALYSTS BOREALIS AG (AT) 2013-01-17 WO disclosed