SCHEMBL14645969

SCHEMBL14645969

COc1c(C(C)(C)C)cc2c(c1-c1ccccc1)C=C(C)C2[SiH](C)C

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 6/20 0.37
PDE4A P27815 5/20 0.37
PDE4C Q08493 5/20 0.37
PDE4D Q08499 5/20 0.37
TNFRSF1A P19438 1/20 0.33
ALDH1A1 P00352 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17286312 0.86 PDE4B (0.38) PDE4BPDE4APDE4CPDE4DTNFRSF1A
SCHEMBL30288196 0.86 PTGS2 (0.30)
SCHEMBL17409306 0.85 PDE4B (0.37) PDE4BPDE4APDE4CPDE4DTNFRSF1A
SCHEMBL17627164 0.85 PDE4A (0.33) PDE4BPDE4APDE4CPDE4DTNFRSF1A
SCHEMBL15893458 0.84
Hydrochloric Acid SCHEMBL22653349 0.84 PDE4B (0.36) PDE4BPDE4APDE4CPDE4DTNFRSF1A
Hydrochloric Acid SCHEMBL16286923 0.84 PDE4B (0.36) PDE4BPDE4APDE4CPDE4DTNFRSF1A
SCHEMBL191820 0.83 PDE4A (0.32) PDE4BPDE4APDE4CPDE4D
SCHEMBL9956263 0.83 PDE4A (0.32) PDE4BPDE4APDE4CPDE4D
SCHEMBL15700813 0.83 PDE4B (0.35) PDE4BPDE4APDE4CPDE4DTNFRSF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9567351-B2 Heterophasic copolymers BOREALIS AG (AT) 2017-02-14 US disclosed
US-20140221584-A1 CATALYSTS BOREALIS AG (AT) 2014-08-07 US disclosed
US-20140206819-A1 HETEROPHASIC COPOLYMERS BOREALIS AG (AT) 2014-07-24 US disclosed
EP-2729479-A1 CATALYSTS Borealis AG (AT) 2014-05-14 EP disclosed
WO-2013007650-A1 CATALYSTS BOREALIS AG (AT) 2013-01-17 WO disclosed