Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16002850 | 0.90 | PLK1 (0.52) | HPGDRAB9AKMT2AMEN1MAPT | |
| SCHEMBL1464754 | 0.82 | PLK1 (0.57) | RAB9AKMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL28834772 | 0.79 | HPGD (0.54) | HPGDRAB9AKMT2ASMN1; SMN2MAPT | |
| SCHEMBL5393397 | 0.76 | CYP3A4 (0.47) | HPGDRAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL15996999 | 0.76 | PLK1 (0.48) | HPGDMAPTKDM4EALDH1A1PLK1 | |
| SCHEMBL7997525 | 0.76 | SLC6A5 (0.50) | RAB9AKMT2AMEN1MAPTNPC1 | |
| SCHEMBL17715248 | 0.76 | CASP1 (0.36) | HPGDRAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL29901789 | 0.75 | KDM4E (0.53) | HPGDRAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9512531 | 0.75 | KDM4E (0.53) | HPGDRAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17714985 | 0.75 | RAB9A (0.49) | HPGDRAB9AKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328084-B2 | Nitrogen-containing biphenyl compounds, pharmaceutical compositions of same, preparation methods and anti-HIV-1 uses thereof | KUNMING INSTITUTE OF BOTANY, THE CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-03 | — | — | US | disclosed |