Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648182 | 0.94 | LMNA (0.42) | LMNAACP3CYP2C19CYP2D6CYP3A4 | |
| SCHEMBL14648252 | 0.89 | NPC1 (0.42) | LMNAACP3GAAACHE | |
| SCHEMBL14648198 | 0.88 | CYP2D6 (0.36) | LMNAACP3CYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL14648215 | 0.88 | ALDH1A1 (0.39) | LMNAACP3GAAALDH1A1 | |
| SCHEMBL14648205 | 0.88 | LMNA (0.45) | LMNACYP3A4ALDH1A1 | |
| SCHEMBL14648204 | 0.87 | STAT3 (0.41) | LMNASTAT3ALDH1A1ACHE | |
| SCHEMBL14648290 | 0.87 | IDO1 (0.42) | LMNAGAAHSD17B10ALDH1A1 | |
| SCHEMBL14648277 | 0.87 | TRPM8 (0.40) | ACP3ALDH1A1 | |
| SCHEMBL14648170 | 0.86 | L3MBTL1 (0.43) | ALDH1A1ACHE | |
| SCHEMBL14648303 | 0.86 | TRPM8 (0.40) | LMNAACP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906970-B1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2016-11-23 | — | — | EP | claimed |
| EP-2906970-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | Novartis AG (CH) | 2015-08-19 | — | — | EP | claimed |
| WO-2014062151-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2014-04-24 | — | — | WO | claimed |
| US-20130030079-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2013-01-31 | — | — | US | claimed |
| US-8362177-B1 | High refractive index ophthalmic device materials with reduced tack | NOVARTIS AG (CH) | 2013-01-29 | — | — | US | claimed |
| EP-2906970-B1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2016-11-23 | — | — | EP | disclosed |
| EP-2906970-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | Novartis AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014062151-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| US-20130030079-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS WITH REDUCED TACK | NOVARTIS AG (CH) | 2013-01-31 | — | — | US | disclosed |
| US-8362177-B1 | High refractive index ophthalmic device materials with reduced tack | NOVARTIS AG (CH) | 2013-01-29 | — | — | US | disclosed |