Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.66 |
| ▸ | RAB9A | P51151 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424894 | 0.80 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL14955713 | 0.68 | MAPT (0.74) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL13186367 | 0.67 | TP53 (0.66) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL16071464 | 0.67 | MAPT (0.66) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL2248037 | 0.66 | F10 (0.69) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL10016378 | 0.66 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL426549 | 0.65 | MAPT (0.63) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL425769 | 0.65 | MEN1 (0.77) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL24886328 | 0.65 | RAB9A (0.71) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL17772176 | 0.65 | HTT (0.63) | NPC1RAB9AMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | The Wistar Institute and North Carolina State University | 2013-01-24 | — | — | US | disclosed |
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | The Wistar Institute and North Carolina State University | 2013-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023498-A1 | MicroRNA Modulators and Method for Identifying and Using the Same | AGO2, RNASE1, TRDMT1 | NPC1 667/4885RAB9A 2435/4885MEN1 1708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.