Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15203457 | 0.86 | DPP4 (0.35) | DPP4 | |
| SCHEMBL17152270 | 0.78 | PDK1 (0.38) | — | |
| SCHEMBL14737247 | 0.76 | JAK3 (0.31) | — | |
| SCHEMBL6053655 | 0.74 | ALDH1A1 (0.36) | — | |
| SCHEMBL17152479 | 0.73 | DPP4 (0.47) | DPP4 | |
| SCHEMBL14738007 | 0.73 | — | — | |
| SCHEMBL14152389 | 0.72 | DPP4 (0.34) | DPP4 | |
| SCHEMBL17152299 | 0.72 | HTR1A (0.40) | — | |
| SCHEMBL17152246 | 0.71 | DPP4 (0.38) | DPP4 | |
| SCHEMBL14655415 | 0.71 | JAK3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | claimed |
| EP-2550273-A2 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2013-01-30 | — | — | EP | claimed |
| US-8518945-B2 | Pyrrolopyrazine kinase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2013-08-27 | — | — | US | disclosed |