Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24201870 | 0.79 | HSD17B10 (0.75) | HSD17B10SMN1; SMN2HTR6HTR7ADRA2A | |
| SCHEMBL12090866 | 0.77 | HSD17B10 (0.54) | HSD17B10SMN1; SMN2HTR6HTR7ADRA2A | |
| SCHEMBL19192790 | 0.76 | SMN1; SMN2 (0.53) | HSD17B10SMN1; SMN2HTR6HTR7KDM4E | |
| SCHEMBL24358704 | 0.76 | HTR6 (0.65) | HSD17B10SMN1; SMN2HTR6HTR7ADRA2A | |
| SCHEMBL3116596 | 0.76 | HSD17B10 (0.53) | HSD17B10SMN1; SMN2HTR6HTR7ADRA2A | |
| SCHEMBL17951532 | 0.76 | AR (0.54) | HSD17B10KDM4EALDH1A1MAPTAR | |
| SCHEMBL11374190 | 0.73 | ALDH1A1 (0.78) | HSD17B10SMN1; SMN2HTR6HTR7KDM4E | |
| SCHEMBL30911271 | 0.73 | HSD17B10 (0.50) | HSD17B10SMN1; SMN2HTR6HTR7ADRA2A | |
| SCHEMBL25811506 | 0.71 | KDM4E (0.67) | HSD17B10SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL9175460 | 0.71 | AR (0.48) | HSD17B10KDM4EALDH1A1ARGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 926 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007394-B1 | NOVEL USE OF ANTIHISTAMINE AGENTS FOR THE PREVENTIVE OR EARLY TREATMENT OF INFLAMMATORY SYNDROMES, IN PARTICULAR THOSE TRIGGERED BY TOGAVIRUSES | PF MEDICAMENT (FR) | 2012-10-10 | — | — | EP | claimed |
| US-8242110-B2 | Prevention of alphavirus caused arthritis with antihistamines such as alimemazine; antiserotonin agent and antihistamine combination therapy | PIERRE FABRE MEDICAMENT (FR) | 2012-08-14 | — | — | US | claimed |
| CN-101394854-A | Novel use of antihistamine agents for the preventive or early treatment of inflammatory syndromes, in particular those triggered by togaviruses | PF MEDICAMENT (FR) | 2009-03-25 | — | — | CN | claimed |
| US-20090069308-A1 | Novel Use of Antihistamine Agents for the Preventive or Early Treatment of Inflammatory Syndromes, in Particular Those Triggered by Togaviruses | PIERRE FABRE MEDICAMENT (FR) | 2009-03-12 | — | — | US | claimed |
| CN-1934083-A | 5-amino-4-hydroxy-7- (1H-indolylmethyl) -8-methylnonanamide derivatives as renin inhibitors for the treatment of hypertension | SPEEDEL EXPERIMENTA AG (CH) | 2007-03-21 | — | — | CN | claimed |
| US-5763476-A | TREATMENT OF PSYCHOLOGICAL DISORDERS SUCH AS PSYCHOSIS AND SCHIZOPHRENIA; ASENAPINE | AKZO NOBLE N.V. (NL) | 1998-06-09 | — | — | US | claimed |
| EP-0559055-A1 | N-Deacetyl lysogangliosides for use as medicaments | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-08 | — | — | EP | claimed |
| US-RE30812-E | ANTIARRHTHMIA AGENTS | MEAD JOHNSON & COMPANY (US) | 1981-12-01 | — | — | US | claimed |
| US-RE30811-E | SEROTONIN ANTAGONISTS, ANTIARRHYTHMIA AGENTS | MEAD JOHNSON & COMPANY (US) | 1981-12-01 | — | — | US | claimed |
| US-4294828-A | ANTIEMETIC AND ANTISEROTONIN | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE DE-FRANCE (FR) | 1981-10-13 | — | — | US | claimed |
| US-4162311-A | Medicinal preparation with pronounced vegetotropic and antiepileptic effect for treating psychoneurotic disorders | AVRUTSKY GRIGORY Y (SU) | 1979-07-24 | — | — | US | claimed |
| US-4148903-A | Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines | MERCK & CO., INC. (US) | 1979-04-10 | — | — | US | claimed |
| US-4104398-A | 3-Lower alkoxycyproheptadines as serotonin inhibitors | MERCK & CO., INC. (US) | 1978-08-01 | — | — | US | claimed |
| US-4064254-A | ANTIARRHYTHMIC AND ANTISEROTONINE AGENTS | MEAD JOHNSON & COMPANY (US) | 1977-12-20 | — | — | US | claimed |
| US-4038402-A | METHOD OF EFFECTING ANTIHISTAMINIC, ANTISEROTONIN AND ANTIALLERGIC ACTIONS | KAMINKA MIKHAIL EMMANUILOVICH | 1977-07-26 | — | — | US | claimed |
| JP-6166687-A | — | — | None | — | — | JP | disclosed |
| JP-56095188-A | — | — | None | — | — | JP | disclosed |
| US-3931195-A | ANTIARRHYTHMIA, ANTISEROTONIN | MEAD JOHNSON & COMPANY (US) | 1976-01-06 | — | — | US | disclosed |
| US-3931195-A | ANTIARRHYTHMIA, ANTISEROTONIN | MEAD JOHNSON & COMPANY (US) | 1976-01-06 | — | — | US | disclosed |
| US-3894032-A | 10,11-Furo derivatives of cyproheptadine | MERCK & CO INC | 1975-07-08 | — | — | US | disclosed |