Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.54 |
| ▸ | RHEB | Q15382 | 1/20 | 0.50 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655142 | 0.89 | NPSR1 (0.53) | DGAT1KCNH2SOAT1NPSR1KDM4E | |
| SCHEMBL1842081 | 0.80 | RHEB (0.59) | DGAT1KCNH2SOAT1RHEBPKN1 | |
| SCHEMBL14669313 | 0.79 | NPSR1 (0.45) | DGAT1KCNH2SOAT1CHEK2NPSR1 | |
| SCHEMBL14669363 | 0.79 | HPGD (0.47) | DGAT1KCNH2SOAT1NPSR1KDM4E | |
| SCHEMBL20982583 | 0.79 | RHEB (0.70) | DGAT1KCNH2SOAT1RHEBPKN1 | |
| SCHEMBL14669436 | 0.78 | RHEB (0.51) | DGAT1KCNH2SOAT1RHEBPKN1 | |
| SCHEMBL15245239 | 0.78 | DGAT1 (0.81) | DGAT1KCNH2SOAT1RHEBPKN1 | |
| SCHEMBL14669435 | 0.78 | RHEB (0.51) | DGAT1KCNH2SOAT1RHEBPKN1 | |
| SCHEMBL7655150 | 0.78 | ALDH1A1 (0.58) | DGAT1KCNH2SOAT1PKN1PKN2 | |
| SCHEMBL6061802 | 0.77 | RHEB (0.57) | DGAT1KCNH2SOAT1RHEBPKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9056887-B2 | Minor groove binder phosphoramidites and methods of use | ELITECH HOLDING B.V. (NL) | 2015-06-16 | — | — | US | disclosed |
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | ELITECH HOLDING B.V. | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030166-A1 | MINOR GROOVE BINDER PHOSPHORAMIDITES AND METHODS OF USE | PCNA, CD2BP2, BPGM | DGAT1 3497/4885KCNH2 4673/4885SOAT1 3480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.