Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17302914 | 0.87 | LTA4H (0.50) | LTA4HTTRMMP2MMP3MMP7 | |
| SCHEMBL16918059 | 0.83 | S1PR1 (0.39) | S1PR1S1PR3ST14SOS1 | |
| SCHEMBL5125208 | 0.82 | LTA4H (0.57) | LTA4HTTRMMP2MMP3MMP7 | |
| SCHEMBL16918204 | 0.79 | TEAD4 (0.42) | SOS1MEN1KMT2A | |
| SCHEMBL14661841 | 0.78 | LTA4H (0.52) | LTA4HTTRSOS1NR1H2NR1H3 | |
| SCHEMBL14656122 | 0.78 | LTA4H (0.52) | LTA4HTTRMMP2MMP3MMP7 | |
| SCHEMBL507575 | 0.76 | LTA4H (0.53) | LTA4HTTRRHEBNR1H2MEN1 | |
| SCHEMBL15813735 | 0.75 | KIF11 (0.64) | LTA4HKIF11NR1H2NR1H3 | |
| SCHEMBL5342317 | 0.75 | LTA4H (0.81) | LTA4HTTRMMP2MMP3MMP7 | |
| SCHEMBL16663703 | 0.75 | HTR2A (0.43) | RHEBSOS1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013013503-A1 | 2,3-DIHYDROIMIDAZO[1,2-C] PYRIMIDIN-5(1H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-31 | — | — | WO | disclosed |