Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14670022 | 0.83 | LTA4H (0.50) | S1PR1S1PR3ST14SOS1 | |
| SCHEMBL16918204 | 0.83 | TEAD4 (0.42) | SMN1; SMN2SOS1HTR2ASLC6A4KCNH2 | |
| SCHEMBL12967364 | 0.82 | SOS1 (0.50) | SMN1; SMN2NPC1RAB9AST14SOS1 | |
| SCHEMBL15308657 | 0.80 | TRPA1 (0.40) | SMN1; SMN2NPC1RAB9ATAAR1LMNA | |
| SCHEMBL22185418 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AST14SOS1 | |
| SCHEMBL12967229 | 0.78 | SLC6A4 (0.47) | SMN1; SMN2NPC1RAB9ASOS1HTR2A | |
| SCHEMBL4351558 | 0.76 | HTR2A (0.44) | SMN1; SMN2NPC1RAB9AST14SOS1 | |
| SCHEMBL12967181 | 0.75 | KIF11 (0.44) | SMN1; SMN2NPC1RAB9AHTR2ASLC6A4 | |
| SCHEMBL475215 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AST14TAAR1 | |
| SCHEMBL8925998 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AST14TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9309260-B2 | Inhibitors of hepatitis C virus | PRESIDIO PHARMACEUTICALS, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-9085587-B2 | Inhibitors of hepatitis C virus | PRESIDIO PHARMACEUTICALS, INC. (US) | 2015-07-21 | — | — | US | disclosed |