Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 13/20 | 0.57 |
| ▸ | PGR | P06401 | 12/20 | 0.57 |
| ▸ | ESR1 | P03372 | 2/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.57 |
| ▸ | THRA | P10827 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14666086 | 0.92 | AR (0.57) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL14656547 | 0.92 | AR (0.57) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL20235298 | 0.92 | AR (0.57) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL5395107 | 0.92 | AR (0.71) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL5395109 | 0.92 | AR (0.71) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL9647584 | 0.90 | AR (0.62) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL14669177 | 0.89 | AR (0.64) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL14670140 | 0.88 | AR (0.56) | ARNR3C1PGRESR1ESR2 | |
| SCHEMBL22924657 | 0.86 | AR (0.56) | ARNR3C1PGRESR1ESR2 | |
| Aglepristone SCHEMBL13625155 | 0.86 | NR3C1 (0.72) | ARNR3C1PGRESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130029953-A1 | PROGESTERONE ANTAGONISTS | EVESTRA, INC. | 2013-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029953-A1 | PROGESTERONE ANTAGONISTS | PGR, PGRMC2, PGRMC1 | AR 41/4885NR3C1 37/4885PGR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.