Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C9 | P02748 | 3/20 | 1.00 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755165 | 0.71 | KDM4E (0.67) | C9AGO2KDM4EALDH1A1HPGD | |
| SCHEMBL12880701 | 0.66 | PTPN1 (0.50) | C9AGO2KDM4EALDH1A1HPGD | |
| SCHEMBL9314378 | 0.65 | ALDH1A1 (0.59) | C9KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9654462 | 0.65 | ALDH1A1 (0.59) | C9KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11489364 | 0.64 | ALDH1A1 (0.57) | C9KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11481523 | 0.63 | KDM4E (0.56) | C9AGO2KDM4EALDH1A1HPGD | |
| Aurintricarboxylic Acid SCHEMBL98495 | 0.62 | MEN1 (1.00) | C9AGO2KDM4EALDH1A1HPGD | |
| Aurintricarboxylic Acid SCHEMBL29353681 | 0.62 | MEN1 (1.00) | C9AGO2KDM4EALDH1A1HPGD | |
| Aurintricarboxylic Acid SCHEMBL29450069 | 0.62 | MEN1 (1.00) | C9AGO2KDM4EALDH1A1HPGD | |
| SCHEMBL5992669 | 0.62 | AGO2 (1.00) | C9AGO2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872130-A1 | SELECTIVE INHIBITION OF THE MEMBRANE ATTACK COMPLEX OF COMPLEMENT AND C3 CONVERTASE BY LOW MOLECULAR WEIGHT COMPONENTS OF THE AURIN TRICARBOXYLIC ACID SYNTHETIC COMPLEX | Aurin Biotech Inc. (CA) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009779-A1 | SELECTIVE INHIBITION OF THE MEMBRANE ATTACK COMPLEX OF COMPLEMENT AND C3 CONVERTASE BY LOW MOLECULAR WEIGHT COMPONENTS OF THE AURIN TRICARBOXYLIC ACID SYNTHETIC COMPLEX | AURIN BIOTECH INC. (CA) | 2014-01-16 | — | — | WO | disclosed |
| US-20130035388-A1 | Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex | AURIN BIOTECH INC. (CA) | 2013-02-07 | — | — | US | disclosed |