Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782256 | 0.84 | — | — | |
| SCHEMBL1225459 | 0.72 | — | — | |
| SCHEMBL419791 | 0.70 | — | — | |
| SCHEMBL3923279 | 0.70 | ALDH1A1 (0.40) | — | |
| SCHEMBL1230286 | 0.69 | — | — | |
| Tromethamine SCHEMBL5428915 | 0.65 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| SCHEMBL4599845 | 0.65 | ALDH1A1 (0.36) | — | |
| SCHEMBL27543111 | 0.65 | — | — | |
| Tromethamine SCHEMBL1019777 | 0.64 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL571834 | 0.64 | MEN1 (0.77) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844218-B2 | Single-component moisture curable silane sealant plasticized with hydrolysable polyether monosilanes | DOW GLOBAL TECHNOLOGIES LLC (US) | 2020-11-24 | — | — | US | disclosed |
| EP-2739683-A2 | SIZING COMPOSITION FOR CHARGES USED IN THERMOPLASTIC POLYMERIC MATERIAL REINFORCEMENT, REINFORCED POLYMERIC MATERIALS AND METHOD OF MANUFACTURE | 3B-Fibreglass SPRL (BE) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013017471-A2 | SIZING COMPOSITION FOR CHARGES USED IN THERMOPLASTIC POLYMERIC MATERIAL REINFORCEMENT, REINFORCED POLYMERIC MATERIALS AND METHOD OF MANUFACTURE | 3B-FIBREGLASS SPRL (BE) | 2013-02-07 | — | — | WO | disclosed |