Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL1019777 | 0.92 | MEN1 (0.77) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL3705445 | 0.89 | MEN1 (0.71) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL7193959 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL28216031 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL3696191 | 0.88 | — | — | |
| Tromethamine SCHEMBL17484 | 0.88 | MEN1 (1.00) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL975 | 0.88 | — | — | |
| Alcohol SCHEMBL18575663 | 0.86 | MEN1 (0.56) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL4634564 | 0.86 | MEN1 (0.67) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL11647748 | 0.86 | MEN1 (0.67) | MEN1LMNAKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115928441-A | Cotton fabric with super-hydrophobic and antibacterial functions and preparation method thereof | 广东省人民医院 | 2023-04-07 | — | — | CN | claimed |
| CN-113476659-B | Artificial biological valve treatment method | 四川大学 | 2022-09-13 | — | — | CN | claimed |
| CN-113476659-A | Artificial biological valve treatment method | 四川大学 | 2021-10-08 | — | — | CN | claimed |
| CN-113430193-A | Nucleic acid collection kit and use method thereof | 上海农林职业技术学院 | 2021-09-24 | — | — | CN | claimed |
| CN-105722530-A | Designed peptides for tight junction barrier modulation | 罗切斯特大学 | 2016-06-29 | — | — | CN | claimed |
| EP-3033108-A2 | DESIGNED PEPTIDES FOR TIGHT JUNCTION BARRIER MODULATION | University Of Rochester (US) | 2016-06-22 | — | — | EP | claimed |
| WO-2015024022-A9 | DESIGNED PEPTIDES FOR TIGHT JUNCTION BARRIER MODULATION | UNIVERSITY OF ROCHESTER (US) | 2016-05-06 | — | — | WO | claimed |
| US-20160000777-A1 | METHODS OF USING HISTAMINE RECEPTOR AGONISTS AND ANTAGONISTS | UNIVERSITY OF ROCHESTER (US) | 2016-01-07 | — | — | US | claimed |
| EP-2908853-A1 | THY1 (CD90) AS A NOVEL THERAPY TO CONTROL ADIPOSE TISSUE ACCUMULATION | University Of Rochester (US) | 2015-08-26 | — | — | EP | claimed |
| WO-2015024022-A2 | DESIGNED PEPTIDES FOR TIGHT JUNCTION BARRIER MODULATION | UNIVERSITY OF ROCHESTER (US) | 2015-02-19 | — | — | WO | claimed |
| WO-2011097595-A1 | METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION | UNIVERSITY OF ROCHESTER (US) | 2011-08-11 | — | — | WO | claimed |
| CN-101304734-A | Transdermal drug delivery devices containing O-desmethyl venlafaxine (ODV) or its salts | WYETH CORP (US) | 2008-11-12 | — | — | CN | claimed |
| CN-101300002-A | Topical formulations containing O-desmethyl venlafaxine (ODV) or its salts | WYETH CORP (US) | 2008-11-05 | — | — | CN | claimed |
| EP-1924251-A1 | TOPICAL FORMULATIONS CONTAINING O-DESMETHYL VENLAFAXINE (ODV) OR ITS SALTS | Wyeth a Corporation of the State of Delaware (US) | 2008-05-28 | — | — | EP | claimed |
| EP-1924249-A2 | TRANSDERMAL DRUG DELIVERY DEVICES CONTAINING O-DESMETHYL VENLAFAXINE (ODV) OR ITS SALTS | Wyeth a Corporation of the State of Delaware (US) | 2008-05-28 | — | — | EP | claimed |
| WO-2007030434-A2 | TRANSDERMAL DRUG DELIVERY DEVICES CONTAINING O-DESMETHYL VENLAFAXINE (ODV) OR ITS SALTS | WYETH (US) | 2007-03-15 | — | — | WO | claimed |
| WO-2007030537-A1 | TOPICAL FORMULATIONS CONTAINING O-DESMETHYL VENLAFAXINE (ODV) OR ITS SALTS | WYETH (US) | 2007-03-15 | — | — | WO | claimed |
| US-20070054964-A1 | Topical formulations containing O-Desmethyl Venlafaxine (ODV) or its salts | WYETH (US) | 2007-03-08 | — | — | US | claimed |
| US-20070053968-A1 | Transdermal drug delivery devices containing O-Desmethyl Venlafaxine (ODV) or its salts | WYETH (US) | 2007-03-08 | — | — | US | claimed |
| US-6645507-B2 | Film that ionically bonds to skin comprising one or more active agents, a nonionic first film forming component, cationic surfactants comprising fatty moieties that are soluble in the first film forming component, carrier | AMERICAN MEDICAL RESEARCH, INC. | 2003-11-11 | — | — | US | claimed |