Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.60 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.44 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.60 |
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | PNMT | P11086 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22264987 | 0.86 | BCHE (0.51) | BCHEACHEIDO1PNMTTAAR1 | |
| SCHEMBL31658954 | 0.84 | IDO1 (0.50) | BCHEACHEIDO1PNMTTAAR1 | |
| Hydrochloric Acid SCHEMBL7166508 | 0.83 | ACHE (0.50) | BCHEACHEIDO1PNMTTAAR1 | |
| Hydrochloric Acid SCHEMBL11140883 | 0.80 | KMT2A (0.61) | BCHEACHESLC6A2SLC6A4CHRM2 | |
| Hydrochloric Acid SCHEMBL8615986 | 0.78 | CYP2D6 (0.61) | BCHEACHEIDO1PNMTTAAR1 | |
| SCHEMBL212194 | 0.76 | CYP2D6 (0.63) | BCHEACHEIDO1PNMTTAAR1 | |
| SCHEMBL9478319 | 0.74 | IDO1 (0.50) | BCHEACHEIDO1PNMTTAAR1 | |
| Hydrochloric Acid SCHEMBL9663575 | 0.74 | BCHE (0.46) | BCHEACHEIDO1PNMTTAAR1 | |
| SCHEMBL30633058 | 0.70 | — | — | |
| SCHEMBL91282 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107011176-B | Process for preparing ring-halogenated N, N-dialkylbenzylamines | 朗盛德国有限责任公司 | 2021-07-06 | — | — | CN | disclosed |
| EP-2739602-B1 | METHOD FOR PRODUCING RING-HALOGENATED N,N-DIALKYLBENZYLAMINES | LANXESS DEUTSCHLAND GMBH (DE) | 2017-08-30 | — | — | EP | disclosed |
| US-9040751-B2 | Method for producing ring-halogenated N,N-dialkylbenzylamines | LANXESS DEUTSCHLAND GMBH (US) | 2015-05-26 | — | — | US | disclosed |
| US-20140221691-A1 | METHOD FOR PRODUCING RING-HALOGENATED N,N-DIALKYLBENZYLAMINES | LANXESS DEUTSCHLAND GMBH (DE) | 2014-08-07 | — | — | US | disclosed |
| EP-2739602-A1 | METHOD FOR PRODUCING RING-HALOGENATED N,N-DIALKYLBENZYLAMINES | LANXESS Deutschland GmbH (DE) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013017611-A1 | METHOD FOR PRODUCING RING-HALOGENATED N,N-DIALKYLBENZYLAMINES | LANXESS DEUTSCHLAND GMBH (DE) | 2013-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221691-A1 | METHOD FOR PRODUCING RING-HALOGENATED N,N-DIALKYLBENZYLAMINES | NPM1, UGT1A6, NNMT | ACHE 502/4885SLC6A2 1777/4885CHRM2 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.