SCHEMBL14675487

SCHEMBL14675487

CNC(=O)c1ccc(-c2ccc(OC(=O)ON3C(=O)CCC3=O)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.46
TSHR P16473 1/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
PLK1 P53350 5/20 0.45
MMP13 P45452 1/20 0.42
CRBN Q96SW2 1/20 0.40
P2RX7 Q99572 2/20 0.39
MKNK1 Q9BUB5 1/20 0.39
MKNK2 Q9HBH9 1/20 0.39
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
GLA P06280 1/20 0.38
HRH3 Q9Y5N1 2/20 0.37
KCNH2 Q12809 1/20 0.37
HSD17B10 Q99714 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12421900 0.96 HPGD (0.50) HPGDTSHRHTTSMN1; SMN2PLK1
SCHEMBL14675648 0.84 RAB9A (0.51) HPGDTSHRSMN1; SMN2HRH3KCNH2
SCHEMBL12414355 0.83 CA1 (0.39) HPGDHTTSMN1; SMN2PLK1MMP13
SCHEMBL277428 0.82 SMN1; SMN2 (0.41) HPGDSMN1; SMN2GLANPSR1
SCHEMBL13649518 0.81 KMT2A (0.47) TSHRHTTSMN1; SMN2HDAC8HDAC6
SCHEMBL2607958 0.80 GLA (0.46) HPGDTSHRSMN1; SMN2GLAHSD17B10
SCHEMBL14755842 0.80 SRD5A1 (0.47) HPGDSMN1; SMN2GLAKDM4EALDH1A1
SCHEMBL12410677 0.79 HPGD (0.48) HPGDHTTSMN1; SMN2ALDH1A1
SCHEMBL17462699 0.78 MMP13 (0.49) HPGDHTTSMN1; SMN2MMP13GLA
SCHEMBL7109646 0.77 PARP10 (0.46) GLAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2739608-B1 INSULIN SECRETION PROMOTING AGENTS VAL-CHUM LTD PARTNERSHIP (CA) 2017-09-06 EP disclosed
EP-2739608-B1 INSULIN SECRETION PROMOTING AGENTS VAL-CHUM LTD PARTNERSHIP (CA) 2017-09-06 EP disclosed
US-9518016-B2 Insulin secretion promoting agents VAL-CHUM, LIMITED PARTNERSHIP (CA) 2016-12-13 US disclosed
US-9518016-B2 Insulin secretion promoting agents VAL-CHUM, LIMITED PARTNERSHIP (CA) 2016-12-13 US disclosed
US-9518016-B2 Insulin secretion promoting agents VAL-CHUM, LIMITED PARTNERSHIP (CA) 2016-12-13 US disclosed
US-20160264527-A1 INSULIN SECRETION PROMOTING AGENTS CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CA) 2016-09-15 US disclosed
US-20160264527-A1 INSULIN SECRETION PROMOTING AGENTS CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CA) 2016-09-15 US disclosed
US-20160264527-A1 INSULIN SECRETION PROMOTING AGENTS CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CA) 2016-09-15 US disclosed
US-9371285-B2 Insulin secretion promoting agents VAL-CHUM, LIMITED PARTNERSHIP (CA) 2016-06-21 US disclosed
US-9371285-B2 Insulin secretion promoting agents VAL-CHUM, LIMITED PARTNERSHIP (CA) 2016-06-21 US disclosed
US-9371285-B2 Insulin secretion promoting agents VAL-CHUM, LIMITED PARTNERSHIP (CA) 2016-06-21 US disclosed
WO-2015127559-A1 ABHD6 ANTAGONISTS FOR PROMOTING BROWNING OF WHITE ADIPOSE TISSUE AND BROWN ADIPOSE TISSUE FUNCTIONALITY VAL-CHUM, LIMITED PARTNERSHIP (CA) 2015-09-03 WO disclosed
WO-2015127559-A1 ABHD6 ANTAGONISTS FOR PROMOTING BROWNING OF WHITE ADIPOSE TISSUE AND BROWN ADIPOSE TISSUE FUNCTIONALITY VAL-CHUM, LIMITED PARTNERSHIP (CA) 2015-09-03 WO disclosed
US-20140163077-A1 INSULIN SECRETION PROMOTING AGENTS VAL-CHUM, LIMITED PARTNERSHIP (CA) 2014-06-12 US disclosed
US-20140163077-A1 INSULIN SECRETION PROMOTING AGENTS VAL-CHUM, LIMITED PARTNERSHIP (CA) 2014-06-12 US disclosed
US-20140163077-A1 INSULIN SECRETION PROMOTING AGENTS VAL-CHUM, LIMITED PARTNERSHIP (CA) 2014-06-12 US disclosed
EP-2739608-A1 INSULIN SECRETION PROMOTING AGENTS Centre Hospitalier de l'Université de Montréal (CA) 2014-06-11 EP disclosed
WO-2013016807-A1 INSULIN SECRETION PROMOTING AGENTS CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CA) 2013-02-07 WO disclosed
WO-2013016807-A1 INSULIN SECRETION PROMOTING AGENTS CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (CA) 2013-02-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160264527-A1 INSULIN SECRETION PROMOTING AGENTS IAPP, GPR119, PNLIP HPGD 1875/4885TSHR 1100/4885HTT 2598/4885
US-20140163077-A1 INSULIN SECRETION PROMOTING AGENTS IAPP, GPR119, PNLIP HPGD 1875/4885TSHR 1100/4885HTT 2598/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.