Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.61 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14676268 | 0.86 | KDM4E (0.68) | KDM4ECYP26A1CYP26B1FFAR1S1PR1 | |
| SCHEMBL979562 | 0.81 | PIM1 (0.59) | KDM4EFFAR1S1PR1PIM1PIM2 | |
| SCHEMBL25795646 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1NPC1MAPK1TP53 | |
| SCHEMBL2434363 | 0.77 | KDM4E (0.82) | KDM4EALDH1A1NPC1MAPK1NAPRT | |
| SCHEMBL15867533 | 0.76 | CYP19A1 (0.51) | KDM4EPIM1PIM2ALDH1A1NPC1 | |
| SCHEMBL14677656 | 0.76 | CYP26A1 (0.50) | KDM4ECYP26A1CYP26B1FFAR1S1PR1 | |
| SCHEMBL22701132 | 0.76 | CYP26B1 (1.00) | CYP26A1CYP26B1FFAR1MAOAMAOB | |
| SCHEMBL14684905 | 0.75 | CYP26A1 (0.52) | KDM4ECYP26A1CYP26B1PIM1PIM2 | |
| SCHEMBL981462 | 0.74 | CYP19A1 (0.64) | KDM4ES1PR1PIM1PIM2ALDH1A1 | |
| SCHEMBL3941960 | 0.74 | NAPRT (0.67) | KDM4EPIM1PIM2ALDH1A1NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140315881-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. | 2014-10-23 | — | — | US | disclosed |
| EP-2736330-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2014-06-04 | — | — | EP | disclosed |
| WO-2013019682-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315881-A1 | COMPOUNDS AND METHODS | RORC, RORB, RORA | KDM4E 1952/4885CYP26A1 165/4885CYP26B1 108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.