Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679115 | 0.91 | NPC1 (0.51) | L3MBTL1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3034762 | 0.82 | HPGD (0.43) | NPC1RAB9APOLBALDH1A1THRA | |
| SCHEMBL8040399 | 0.82 | SIGMAR1 (0.57) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL14679108 | 0.81 | L3MBTL1 (0.61) | L3MBTL1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL21527579 | 0.81 | POLB (0.44) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL31059259 | 0.80 | ALDH1A1 (0.43) | SMN1; SMN2KMT2AALDH1A1HPGDHDAC3 | |
| SCHEMBL14679111 | 0.80 | L3MBTL1 (0.67) | L3MBTL1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL16380444 | 0.80 | TMEM97 (0.53) | NPC1SMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL1408696 | 0.80 | ALDH1A1 (0.57) | LMNAALDH1A1HPGDHDAC3HDAC4 | |
| SCHEMBL17623630 | 0.79 | L3MBTL1 (0.57) | L3MBTL1NPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |