Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.60 |
| ▸ | THRB | P10828 | 8/20 | 0.60 |
| ▸ | RARB | P10826 | 6/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679133 | 0.93 | THRA (0.71) | THRATHRBRARBHAO1ALDH1A1 | |
| SCHEMBL7633932 | 0.85 | PLK1 (0.68) | THRATHRBRARBPLK1HAO1 | |
| SCHEMBL10031544 | 0.85 | THRA (0.64) | THRATHRBRARBPLK1HAO1 | |
| SCHEMBL30089476 | 0.85 | THRA (0.70) | THRATHRBRARBPLK1HAO1 | |
| SCHEMBL12563620 | 0.83 | ALDH1A1 (0.67) | THRATHRBRARBPLK1HAO1 | |
| SCHEMBL83484 | 0.83 | THRA (0.68) | THRATHRBRARBPLK1HAO1 | |
| SCHEMBL27634917 | 0.83 | THRA (0.62) | THRATHRBRARBPLK1HAO1 | |
| SCHEMBL12648743 | 0.82 | RARB (0.65) | THRATHRBRARBPLK1ALDH1A1 | |
| SCHEMBL9331746 | 0.81 | THRA (0.87) | THRATHRBRARBPLK1HAO1 | |
| SCHEMBL3011724 | 0.81 | THRA (0.66) | THRATHRBRARBPLK1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367713-B2 | Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives | NORTH CAROLINA STATE UNIVERSITY (US) | 2013-02-05 | — | — | US | disclosed |