Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23192712 | 0.84 | KMT2A (0.54) | ALDH1A1KMT2AMEN1LMNANPC1 | |
| SCHEMBL14679457 | 0.82 | ALDH1A1 (0.51) | ALDH1A1APEX1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL19334504 | 0.82 | ALDH1A1 (0.64) | ALDH1A1USP2APEX1CYP1A2CYP3A4 | |
| SCHEMBL3112488 | 0.81 | TPSAB1 (0.44) | ALDH1A1USP2CYP3A4CYP2C19KMT2A | |
| SCHEMBL17335992 | 0.78 | CYP3A4 (0.63) | ALDH1A1USP2CYP3A4CYP2C19KMT2A | |
| SCHEMBL14853358 | 0.77 | ALDH1A1 (0.58) | ALDH1A1USP2APEX1CYP1A2CYP3A4 | |
| SCHEMBL5326701 | 0.77 | HTT (0.70) | ALDH1A1USP2CYP2C19KMT2AMEN1 | |
| SCHEMBL14679156 | 0.77 | TPSAB1 (0.62) | ALDH1A1USP2APEX1CYP1A2CYP3A4 | |
| SCHEMBL11731507 | 0.76 | KMT2A (0.65) | ALDH1A1USP2KMT2AMEN1LMNA | |
| SCHEMBL11869640 | 0.76 | KMT2A (0.64) | ALDH1A1USP2KMT2AHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |