Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679156 | 0.90 | TPSAB1 (0.62) | TPSAB1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL6467130 | 0.85 | HPGD (0.73) | TPSAB1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL11869640 | 0.85 | KMT2A (0.64) | TPSAB1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL29200529 | 0.83 | LMNA (0.81) | TPSAB1CA1CA2KMT2AMEN1 | |
| SCHEMBL4436696 | 0.83 | GAA (0.79) | TPSAB1CA1CA2KMT2AMEN1 | |
| SCHEMBL18235894 | 0.82 | CA1 (0.62) | TPSAB1CA1CA2KMT2AMEN1 | |
| SCHEMBL6736890 | 0.81 | KMT2A (0.63) | TPSAB1CA1CA2KMT2AMEN1 | |
| SCHEMBL14344692 | 0.81 | TPSAB1 (0.61) | TPSAB1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL17335992 | 0.81 | CYP3A4 (0.63) | KMT2AMEN1LMNAALDH1A1USP2 | |
| SCHEMBL14679454 | 0.81 | KMT2A (0.59) | TPSAB1KMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367668-B2 | Pyridazinone derivatives | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2013-02-05 | — | — | US | disclosed |