Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 11/20 | 0.41 |
| ▸ | NPC1 | O15118 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16403964 | 0.92 | KDM4E (0.49) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16403961 | 0.86 | RAB9A (0.49) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14224952 | 0.85 | KDM4E (0.44) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16404165 | 0.85 | KDM4E (0.44) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16403932 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16403989 | 0.85 | RAB9A (0.41) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16403991 | 0.85 | ALDH1A1 (0.40) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16404058 | 0.84 | SMN1; SMN2 (0.42) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16404149 | 0.84 | NPC1 (0.46) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16403922 | 0.83 | KDM4E (0.61) | ALDH1A1KDM4ERAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012172438-A9 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2013-02-07 | — | — | WO | disclosed |