Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | FABP4 | P15090 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 4/20 | 0.45 |
| ▸ | RXRB | P28702 | 4/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | PTGIR | P43119 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19163857 | 0.88 | KDM4E (0.85) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL674739 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL29640642 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9594904 | 0.82 | KDM4E (0.72) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL27952162 | 0.79 | KDM4E (0.65) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9127459 | 0.77 | KDM4E (0.59) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9006760 | 0.75 | PTGIR (0.73) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9593239 | 0.75 | ALDH1A1 (0.80) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9592678 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9452960 | 0.75 | PPARD (0.56) | KDM4ECYP3A4HPGDFABP4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11318331-B2 | Pulmonary hypertension treatment | SONIVIE LTD. (IL) | 2022-05-03 | — | — | US | disclosed |
| US-20200368244-A1 | PULMONARY HYPERTENSION TREATMENT | Sonie Vie Ltd. (IL) | 2020-11-26 | — | — | US | disclosed |
| EP-3600434-A1 | PULMONARY HYPERTENSION TREATMENT | Sonievie Ltd. (IL) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018173052-A1 | PULMONARY HYPERTENSION TREATMENT | SONIEVIE LTD. (IL) | 2018-09-27 | — | — | WO | disclosed |
| EP-3278112-A2 | A COMPOSITION COMPRISING PROSTACYCLIN OR ANALOGUES THEREOF FOR TREATMENT OF ACUTE CRITICALLY ILL PATIENTS | Ostrowski, Sisse Rye (DK) | 2018-02-07 | — | — | EP | disclosed |
| WO-2016156107-A2 | A COMPOSITION COMPRISING PROSTACYCLIN OR ANALOGUES THEREOF FOR TREATMENT OF ACUTE CRITICALLY ILL PATIENTS | RIGSHOSPITALET (DK) | 2016-10-06 | — | — | WO | disclosed |
| EP-2741738-A1 | SUSTAINED RELEASE COMPOSITION OF PROSTACYCLIN | Ascendis Pharma A/S (DK) | 2014-06-18 | — | — | EP | disclosed |
| WO-2013024051-A1 | SUSTAINED RELEASE COMPOSITION OF PROSTACYCLIN | ASCENDIS PHARMA A/S (DK) | 2013-02-21 | — | — | WO | disclosed |