SCHEMBL674739

SCHEMBL674739

O=C(O)COc1cccc(-c2ocnc2-c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 1.00
MEN1 O00255 1/20 1.00
ALDH1A1 P00352 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
HPGD P15428 1/20 1.00
KMT2A Q03164 1/20 1.00
HSD17B10 Q99714 1/20 1.00
FABP4 P15090 8/20 0.72
PTGIR P43119 8/20 0.52
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
PTGER4 P35408 1/20 0.46
PTGER3 P43115 1/20 0.46
FABP5 Q01469 3/20 0.45
FABP3 P05413 2/20 0.45
PPARD Q03181 1/20 0.44
NR4A1 P22736 1/20 0.43
NR4A2 P43354 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29640642 1.00 KDM4E (1.00) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL19163857 0.92 KDM4E (0.85) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL9428515 0.90 MEN1 (0.82) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL9593239 0.89 ALDH1A1 (0.80) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL9428853 0.86 KDM4E (0.76) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL8066970 0.85 FABP4 (0.79) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL14698129 0.85 KDM4E (0.74) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL9594904 0.84 KDM4E (0.72) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL9428317 0.84 FABP4 (1.00) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL30398835 0.84 FABP4 (1.00) KDM4EMEN1ALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9381243-B2 Methods of identifying critically ill patients at increased risk of development of organ failure and compounds for the treatment hereof RIGSHOSPITALET (DK) 2016-07-05 US claimed
US-20150057325-A1 COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST RIGSHOSPITALET (DK) 2015-02-26 US claimed
EP-2834642-A1 COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST Rigshospitalet (DK) 2015-02-11 EP claimed
US-8877710-B2 Methods of identifying critically ill patients at increased risk of development of organ failure and compounds for the treatment hereof RIGHOSPITALET (DK) 2014-11-04 US claimed
US-20140322207-A1 METHODS OF IDENTIFYING CRITICALLY ILL PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ORGAN FAILURE AND COMPOUNDS FOR THE TREATMENT HEREOF ENDOTHEL PHARMA APS (DK) 2014-10-30 US claimed
EP-2699243-A1 PROSTACYCLIN AND ANALOGS THEREOF ADMINISTERED DURING SURGERY FOR PREVENTION AND TREATMENT OF CAPILLARY LEAKAGE Rigshospitalet (DK) 2014-02-26 EP claimed
US-20140044797-A1 PROSTACYCLIN AND ANALOGS THEREOF ADMINISTERED DURING SURGERY FOR PREVENTION AND TREATMENT OF CAPILLARY LEAKAGE RIGSHOSPITALET (DK) 2014-02-13 US claimed
US-20130261177-A1 COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST RIGSHOSPITALET (DK) 2013-10-03 US claimed
WO-2013143548-A1 COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST RIGSHOSPITALET (DK) 2013-10-03 WO claimed
EP-2622354-A1 COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST Rigshospitalet (DK) 2013-08-07 EP claimed
EP-2563369-A2 METHODS OF TREATMENT OF PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ISCHEMIC EVENTS AND COMPOUNDS HEREOF Thrombologic APS (DK) 2013-03-06 EP claimed
US-20130040898-A1 METHODS OF TREATMENT OF PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ISCHEMIC EVENTS AND COMPOUNDS HEREOF THROMBOLOGIC APS (DK) 2013-02-14 US claimed
WO-2012143012-A1 PROSTACYCLIN AND ANALOGS THEREOF ADMINISTERED DURING SURGERY FOR PREVENTION AND TREATMENT OF CAPILLARY LEAKAGE RIGSHOSPITALET (DK) 2012-10-26 WO claimed
WO-2012041334-A1 COMPOUNDS CAPABLE OF MODULATING/PRESERVING ENDOTHELIAL INTEGRITY FOR USE IN PREVENTION OR TREATMENT OF ACUTE TRAUMATIC COAGULOPATHY AND RESUSCITATED CARDIAC ARREST RIGSHOSPITALET (DK) 2012-04-05 WO claimed
EP-2384196-A2 METHODS OF IDENTIFYING CRITICALLY ILL PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ORGAN FAILURE AND COMPOUNDS FOR THE TREATMENT HEREOF Thrombologic APS (DK) 2011-11-09 EP claimed
US-20110268732-A1 METHODS OF IDENTIFYING CRITICALLY ILL PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ORGAN FAILURE AND COMPOUNDS FOR THE TREATMENT HEREOF THROMBOLOGIC APS (DK) 2011-11-03 US claimed
WO-2011134478-A2 METHODS OF TREATMENT OF PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ISCHEMIC EVENTS AND COMPOUNDS HEREOF THROMBOLOGIC APS (DK) 2011-11-03 WO claimed
WO-2010075861-A2 METHODS OF IDENTIFYING CRITICALLY ILL PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ORGAN FAILURE AND COMPOUNDS FOR THE TREATMENT HEREOF THROMBOLOGIC APS (DK) 2010-07-08 WO claimed
US-11857537-B2 Use of prostacyclin antagonists for treating ocular surface nociception JENIVISION INC. (US) 2024-01-02 US disclosed
WO-2010075861-A2 METHODS OF IDENTIFYING CRITICALLY ILL PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ORGAN FAILURE AND COMPOUNDS FOR THE TREATMENT HEREOF THROMBOLOGIC APS (DK) 2010-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11857537-B2 Use of prostacyclin antagonists for treating ocular surface nociception PTGIR, PTGIS, TRPA1 KDM4E 4665/4885MEN1 4843/4885ALDH1A1 1345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.