Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5623905 | 0.72 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL14698378 | 0.71 | OPRM1 (0.36) | RXRARXRBRXRGCRHR1OPRM1 | |
| SCHEMBL14698041 | 0.71 | TACR1 (0.34) | — | |
| SCHEMBL5133331 | 0.68 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL14698017 | 0.68 | CETP (0.33) | — | |
| SCHEMBL14698162 | 0.67 | AR (0.30) | — | |
| SCHEMBL5042709 | 0.67 | PARP14 (0.38) | CRHR1 | |
| SCHEMBL14707172 | 0.66 | TACR1 (0.33) | — | |
| SCHEMBL5049417 | 0.66 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5132600 | 0.65 | CRHR1 (0.32) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351969-B2 | Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (CETP) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-05-31 | — | — | US | disclosed |
| US-9351969-B2 | Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (CETP) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-05-31 | — | — | US | disclosed |
| US-9351969-B2 | Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (CETP) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-05-31 | — | — | US | disclosed |
| US-20160045488-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-02-18 | — | — | US | disclosed |
| US-20160045488-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-02-18 | — | — | US | disclosed |
| US-20160045488-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-02-18 | — | — | US | disclosed |
| US-9199967-B2 | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-12-01 | — | — | US | disclosed |
| US-9199967-B2 | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-12-01 | — | — | US | disclosed |
| US-9199967-B2 | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2015-12-01 | — | — | US | disclosed |
| US-20140256724-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-09-11 | — | — | US | disclosed |
| US-20140256724-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-09-11 | — | — | US | disclosed |
| US-20140256724-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2014-09-11 | — | — | US | disclosed |
| EP-2744803-A2 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | Dr. Reddy's Laboratories Ltd. (IN) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013024358-A2 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2013-02-21 | — | — | WO | disclosed |
| WO-2013024358-A2 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | DR. REDDY'S LABORATORIES LTD. (IN) | 2013-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160045488-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | CETP, MTTP, PCTP | RXRA 4644/4885RXRB 4224/4885RXRG 4300/4885 |
| US-20140256724-A1 | SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS | CETP, MTTP, PCTP | RXRA 4630/4885RXRB 4208/4885RXRG 4299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.