Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | PLG | P00747 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.70 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.64 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Ketoglutaric Acid SCHEMBL20817532 | 0.95 | EGLN1 (0.70) | NFKB1CYP2D6LMNABLMNPSR1 | |
| Alpha-Ketoglutaric Acid SCHEMBL16412456 | 0.93 | LMNA (0.71) | NFKB1CYP2D6LMNABLMNPSR1 | |
| Alpha-Ketoglutaric Acid SCHEMBL1469855 | 0.93 | LMNA (0.71) | NFKB1CYP2D6LMNABLMNPSR1 | |
| SCHEMBL728991 | 0.85 | NFKB1 (0.62) | NFKB1CYP2D6LMNABLMNPSR1 | |
| Adipic Acid SCHEMBL2537893 | 0.85 | NFKB1 (1.00) | NFKB1CYP2D6LMNABLMNPSR1 | |
| 5-Aminovaleric Acid SCHEMBL190150 | 0.85 | — | — | |
| 5-Aminovaleric Acid SCHEMBL887118 | 0.85 | NFKB1 (1.00) | NFKB1CYP2D6LMNABLMNPSR1 | |
| Alpha-Ketoglutaric Acid SCHEMBL1261453 | 0.83 | EGLN1 (0.74) | NFKB1CYP2D6LMNABLMNPSR1 | |
| SCHEMBL2368877 | 0.83 | LMNA (0.64) | NFKB1CYP2D6LMNABLMNPSR1 | |
| SCHEMBL285020 | 0.83 | LMNA (0.64) | NFKB1CYP2D6LMNABLMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190091300-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2019-03-28 | — | — | US | disclosed |
| US-10159717-B2 | Methods of treating cancer of the central nervous system | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2018-12-25 | — | — | US | disclosed |
| US-20150216949-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-08-06 | — | — | US | disclosed |
| US-9034319-B2 | Methods of treating cancer of the central nervous system | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2015-05-19 | — | — | US | disclosed |
| US-20110070218-A1 | METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2011-03-24 | — | — | US | disclosed |
| US-7767204-B2 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2010-08-03 | — | — | US | disclosed |
| US-20090304661-A1 | Method And Composition For Proctecting Neuronal Tissue From Damage Induced By Elevated Glutamate Levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCEINCE (IL) | 2009-12-10 | — | — | US | disclosed |
| US-20080233096-A1 | transaminase, dehydrogenase, decarboxylase, ligase as glutamate modifying enzymes and oxaloacetate, pyruvate, NAD+, NADP+, 2-oxohexanedioic acid, 2-oxo-3-sulfopropionate, 2-oxo-3-sulfinopropionic acid, 2-oxo-3-phenylpropionic acid co-factors to enhance brain to blood efflux | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-25 | — | — | US | disclosed |
| US-20080233099-A1 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-09-25 | — | — | US | disclosed |
| US-7404951-B2 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2008-07-29 | — | — | US | disclosed |
| US-20060024284-A1 | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2006-02-02 | — | — | US | disclosed |